MAL (NM_022438) Human Untagged Clone

CAT#: SC112547

MAL (untagged)-Human mal, T-cell differentiation protein (MAL), transcript variant b

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: MAL
• Synonyms: MVP17; VIP17
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_022438, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCCCCCGCAGCGGCGACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCG
  ACTTGCTCTTCATCTTTGAGTTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGTGCC
  CTGGCCCCTGGTCCAGGGCTGGGTGATGTTCGTGTCTGTGTTCTGCTTCGTGGCCACCACCACCTTGATC
  ATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTGGGTCACCTTGGTGTTCTCCTACATAGCCA
  CTCTGCTCTACGTGGTCCATGCGGTGTTCTCTTTAATCAGATGGAAGTCTTCATAA
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_022438 unedited
  GGGGTCCCATTAGNATACCATTATATAGGCGGCCGCGNAATTCGCACGAGGCGGAGTCTG
  AGCGGCGCTCGTCCCGTCCCAAGGCCGACGCCAGCACGCCGTCATGGCCCCCGCAGCGGC
  GACGGGGGGCAGCACCCTGCCCAGTGGCTTCTCGGTCTTCACCACCTTGCCCGACTTGCT
  CTTCATCTTTGAGTTTATCTTCGGGGGCCTGGTGTGGATCCTGGTGGCCTCCTCCCTGGT
  GCCCTGGCCCCTGGTCCAGGGCTGGGTGATGTTCGTGTCTGTGTTCTGCTTCGTGGCCAC
  CACCACCTTGATCATCCTGTACATAATTGGAGCCCACGGTGGAGAGACTTCCTGGGTCAC
  CTTGGACGCAGCCTACCACTGCACCGCTGCCCTCTTTTACCTCAGCGCCTCAGTCCTGGA
  GGCCCTGGCCACCATCACGATGCAAGACGGCTTCACCTACAGGCACTACCATGAAAACAT
  TGCTGCCGTGGTGTTCTCCTACATAGCCACTCTGCTCTACGTGGTCCATGCGGTGTTCTC
  TTTATCAGATGGAAGTCTCATAAAGCCGCAGTAGAACTTGAGCTGAAAAACCCAGATGGT
  GTTAACTGCCCGCCCCCACTTTTCGGCATAACTTTTTAGAAAACAGAAATGCCCTTGATG
  GTGGAAAAAAGAAAACAACCACCCCCCCACTGCCCAAAAAAAAAAGCCCTGCCCTGTTGC
  TCGTGGGTGCTGTGTTTACTCTCCCGTGTGCCTTCGCCTCCGGGTTGGGAGCTTGCTGTG
  TCTAACCCTCCACTGCTGTGCTGTCTGCTAAGTTCCACTCCTGTTTGTGAAAGGGGACCT
  TCTTGTTCGGGGGTGGGAAATGGCGACCCCGACCCTGAAAAAGAAAGAAAAACCCTCTG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_022438 unedited
  NGGTACAGCTATGNNACCGCGGCCGCAATCTANGATCGAGTTTTTTTTTTTTTTTTTTGA
  ACATTAAGACTTTTATAAAGTATTTCACAGGGTTATCGTCTTCCACCATGGACCTCTGGA
  AAGATCTGTTGGGTGAGTTTTAGTCCCCATGACATGCAGAACATCCATGAAGACTTAAAA
  CATGGCACAAGATGGGGCGCTCGGGAGAGCTTGTGGACAATACCAACAGGTAGTTCTCGA
  GAGCTGCTCCAGGGGTCAGCAGAGGATCTTTCTTTCCTTCTCAGGTCACGGTCGCCACTT
  CCCACCCCCGAACAAGAAGGTCCCCTTTCACAAACAGGAGGTGACCCTAGCAGACAGCAC
  AGCAGTTGGAGGTTAGACACAGCAAGCTCCCAACCCGGACGCGAAGGCACACGGGAGAGT
  AAACACAGCACCCACGAGCAACAGGGCAGGGCTTTTTTTTTTGGGCAGTGGGGGGGTGGT
  TGTTTTCTTTTTTCCACCATCAAGGGCATTTCTGTTTTCTAAAAAGTTATGCCGGAAAGT
  GGGGCGGCCAGTTAACACCATCTGGGTTTTCAGCTCAAGTTCTACTGCGGCTTTATGAAG
  ACTTCCATCTGATTAAAGAGAACACCGCATGGACCACGTAGAGCAGAGTGGCTATGTAGG
  AGAACACCACGGCAGCAATGTTTTCATGGTAGTGCCTGTAGGTGAAGCCGTCTTGCATCG
  TGATGGTGGCCAGGGCCTCCAGGACTGAGGCGCTGAGGTAAAAGAAGGCAGCGGTGCAGT
  GGTAGGCTGCGTCCAAGTGACCCAGAAGTCTCTCCCCGTGGGCTCAATTATGTACAGGAG
  ATCAAGGTGGTGGTGGCCACGAGCAGACACAGACACGACATCACCAGCCCTGGACCAGGG
  CAGGGCACCAGGC
  
• Restriction Sites: NotI-NotI
• ACCN: NM_022438
• Insert Size: 1050 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_022438.1, NP_071883.1
• RefSeq Size: 930 bp
• RefSeq ORF: 336 bp
• Locus ID: 4118
• UniProt ID: P21145
• Cytogenetics: 2q11.1
• Protein Families: Transmembrane
• Gene Summary: The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]
  Transcript Variant: This variant (b) includes alternatively spliced exon 2 but is missing exon 3, resulting in isoform b which is shorter than the predominant isoform (a).