VKORC1 (NM_024006) Human Untagged Clone

CAT#: SC112318

VKORC1 (untagged)-Human vitamin K epoxide reductase complex, subunit 1 (VKORC1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: VKORC1
• Synonyms: EDTP308; MST134; MST576; VKCFD2; VKOR
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_024006 edited
  ATGGGCAGCACCTGGGGGAGCCCTGGCTGGGTGCGGCTCGCTCTTTGCCTGACGGGCTTA
  GTGCTCTCGCTCTACGCGCTGCACGTGAAGGCGGCGCGCGCCCGGGACCGGGATTACCGC
  GCGCTCTGCGACGTGGGCACCGCCATCAGCTGTTCGCGCGTCTTCTCCTCCAGGTGGGGC
  AGGGGTTTCGGGCTGGTGGAGCATGTGCTGGGACAGGACAGCATCCTCAATCAATCCAAC
  AGCATATTCGGTTGCATCTTCTACACACTACAGCTATTGTTAGGTTGCCTGCGGACACGC
  TGGGCCTCTGTCCTGATGCTGCTGAGCTCCCTGGTGTCTCTCGCTGGTTCTGTCTACCTG
  GCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGCATTGTTTGTATCACCACCTATGCT
  ATCAACGTGAGCCTGATGTGGCTCAGTTTCCGGAAGGTCCAAGAACCCCAGGGCAAGGCT
  AAGAGGCACTGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_024006 unedited
  TATAGGCGGCCGCGGCCCGGCCCCTGCTCCGTGGCTGGTTTTCTCCGCGGGCGCCTCGGG
  CGGAACCTGGAGATAATGGGCAGCACCTGGGGGAGCCCTGGCTGGGTGCGGCTCGCTCTT
  TGCCTGACGGGCTTAGTGCTCTCGCTCTACGCGCTGCACGTGAAGGCGGCGCGCGCCCGG
  GACCGGGATTACCGCGCGCTCTGCGACGTGGGCACCGCCATCAGCTGTTCGCGCGTCTTC
  TCCTCCAGGTGGGGCAGGGGTTTCGGGCTGGTGGAGCATGTGCTGGGACAGGACAGCATC
  CTCAATCAATCCAACAGCATATTCGGTTGCATCTTCTACACACTACAGCTATTGTTAGGT
  TGCCTGCGGACACGCTGGGCCTCTGTCCTGATGCTGCTGAGCTCCCTGGTGTCTCTCGCT
  GGTTCTGTCTACCTGGCCTGGATCCTGTTCTTCGTGCTCTATGATTTCTGCATTGTTTGT
  ATCACCACCTATGCTATCAACGTGAGCCTGATGTGGCTCAGTTTCCGGAAGGTCCAAGAA
  CCCCAGGGCAAGGCTAAGAGGCACTGAGCCCTCAACCCAAGCCAGGCTGACCTCATCTGC
  TTTGCTTTGGCATGTGAGCCTTGCCTAAGGGGGCATATCTGGGTCCCTAGAAGGCCCTAG
  ATGTGGGGCTTCTAGATTACCCCCTCCTCCTGCCATACCCGCACATGACAATGGACCAAA
  TGTGCCACACGCTCGCTCTTTTTTACACCCAGTGCCTCTGACTCTGTCCCCATGGGCTGG
  TCTCCAAAGCTCTN
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_024006 unedited
  NNNCCACTTGNACCCGGCCGCATTCTANGATCGAGTTTTTTTTTTTTTTTTTTTTTTTTT
  TTTTTTTTTTTTTTTTTGATTGATCTAAAAAACTTTATTGCTCAAAACCTTCCCTCCCTG
  GGCAATGGAAAAAGCTTTGGAAACCACCCCATGGGGACAAAGTCAAAGGCACTGGGTGTA
  AAAAAAAACGAGCGTGGGGCACATTTGGTCCATTGTCATGTGCGGGTATGGCAAGAGGAG
  GGGGTAATTTAAAAACCCCACATTTAGGGCCTTTTAGGGACCCAAATATGCCCCCTTAGG
  CAAGGGTCACATGCCAAAGCAAAGCAAATGAGGGCAACCTGGCTTGGGTTGAGGGCTCAA
  TGCCTTTTAACCTTGCCCTGGGGTTCTTGGACCTTTCGGAAACTGAGCCACATTAGGCTC
  ACGTTGATAGCATAGGGGGGGATACAAACAATGCCGAAATCATTGAGCACGAAAAACAGG
  ATCCAGGCCAGGTAAACAGAACCAGCGAGAGACACCAGGGAGCTCAACAGCATTAGGACA
  GAGGCCCAGCGTGTCCGCAGGCAACCTAACAATAGCTGTAGTGTGTAAAAAATGCAACCC
  AATATGCTGTTGGATTGATTGAGGATGCTGTCCTGTCCCAGCACATGCTTCACCAGCCCG
  AAACCCCTGCCCCACCTGGAGGAGAAGACGCGCGAACAGCTGATGGCGGTGCCCACGTCG
  CAAAGCGCGCGGTAATCCCGGTCCGGGCGCGCGCCCGCTTCACGTGCAANGCGTAAAGCG
  AGACACTTAACCCCGTCAGCAAAGAACGAGCCGCACCCACCAGGGCTCCCCCCAGTGGCT
  GCCATTATCTTCAGNTNCGGCCGAGGCGCCCGCGNAGAAACAACCCGGAACAGGGGCCGG
  GCCCGGCCGNCCTATAGGAGGTCGATACAAATTTTGAAGTTCACTAAAGAACTCTGTTTT
  TT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_024006
• Insert Size: 850 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_024006.4, NP_076869.1
• RefSeq Size: 1042 bp
• RefSeq ORF: 492 bp
• Locus ID: 79001
• UniProt ID: Q9BQB6
• Cytogenetics: 16p11.2
• Protein Families: Transmembrane
• Gene Summary: This gene encodes the catalytic subunit of the vitamin K epoxide reductase complex, which is responsible for the reduction of inactive vitamin K 2,3-epoxide to active vitamin K in the endoplasmic reticulum membrane. Vitamin K is a required co-factor for carboxylation of glutamic acid residues by vitamin K-dependent gamma-carboxylase in blood-clotting enzymes. Allelic variation in this gene is associated with vitamin k-dependent clotting factors combined deficiency of 2, and increased resistance or sensitivity to warfarin, an inhibitor of vitamin K epoxide reductase. Pseudogenes of this gene are located on chromosomes 1 and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
  Transcript Variant: This variant (1) lacks an alternate in-frame exon compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.