GABA B Receptor 1 (GABBR1) (NM_001470) Human Untagged Clone

CAT#: SC109253

GABBR1 (untagged)-Human gamma-aminobutyric acid (GABA) B receptor, 1 (GABBR1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GABA B Receptor 1
• Synonyms: GABABR1; GABBR1-3; GB1; GPRC3A
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC109253 sequence for NM_001470 edited (data generated by NextGen Sequencing)
  ATGTTGCTGCTGCTGCTACTGGCGCCACTCTTCCTCCGCCCCCCGGGCGCGGGCGGGGCG
  CAGACCCCCAACGCCACCTCAGAAGGTTGCCAGATCATACACCCGCCCTGGGAAGGGGGC
  ATCAGGTACCGGGGCCTGACTCGGGACCAGGTGAAGGCTATCAACTTCCTGCCAGTGGAC
  TATGAGATTGAGTATGTGTGCCGGGGGGAGCGCGAGGTGGTGGGGCCCAAGGTCCGCAAG
  TGCCTGGCCAACGGCTCCTGGACAGATATGGACACACCCAGCCGCTGTGTCCGAATCTGC
  TCCAAGTCTTATTTGACCCTGGAAAATGGGAAGGTTTTCCTGACGGGTGGGGACCTCCCA
  GCTCTGGACGGAGCCCGGGTGGATTTCCGGTGTGACCCCGACTTCCATCTGGTGGGCAGC
  TCCCGGAGCATCTGTAGTCAGGGCCAGTGGAGCACCCCCAAGCCCCACTGCCAGGTGAAT
  CGAACGCCACACTCAGAACGGCGCGCAGTGTACATCGGGGCACTGTTTCCCATGAGCGGG
  GGCTGGCCAGGGGGCCAGGCCTGCCAGCCCGCGGTGGAGATGGCGCTGGAGGACGTGAAT
  AGCCGCAGGGACATCCTGCCGGACTATGAGCTCAAGCTCATCCACCACGACAGCAAGTGT
  GATCCAGGCCAAGCCACCAAGTACCTATATGAGCTGCTCTACAACGACCCTATCAAGATC
  ATCCTTATGCCTGGCTGCAGCTCTGTCTCCACGCTGGTGGCTGAGGCTGCTAGGATGTGG
  AACCTCATTGTGCTTTCCTATGGCTCCAGCTCACCAGCCCTGTCAAACCGGCAGCGTTTC
  CCCACTTTCTTCCGAACGCACCCATCAGCCACACTCCACAACCCTACCCGCGTGAAACTC
  TTTGAAAAGTGGGGCTGGAAGAAGATTGCTACCATCCAGCAGACCACTGAGGTCTTCACT
  TCGACTCTGGACGACCTGGAGGAACGAGTGAAGGAGGCTGGAATTGAGATTACTTTCCGC
  CAGAGTTTCTTCTCAGATCCAGCTGTGCCCGTCAAAAACCTGAAGCGCCAGGATGCCCGA
  ATCATCGTGGGACTTTTCTATGAGACTGAAGCCCGGAAAGTTTTTTGTGAGGTGTACAAG
  GAGCGTCTCTTTGGGAAGAAGTACGTCTGGTTCCTCATTGGGTGGTATGCTGACAATTGG
  TTCAAGATCTACGACCCTTCTATCAACTGCACAGTGGATGAGATGACTGAGGCGGTGGAG
  GGCCACATCACAACTGAGATTGTCATGCTGAATCCTGCCAATACCCGCAGCATTTCCAAC
  ATGACATCCCAGGAATTTGTGGAGAAACTAACCAAGCGACTGAAAAGACACCCTGAGGAG
  ACAGGAGGCTTCCAGGAGGCACCGCTGGCCTATGATGCCATCTGGGCCTTGGCACTGGCC
  CTGAACAAGACATCTGGAGGAGGCGGCCGTTCTGGTGTGCGCCTGGAGGACTTCAACTAC
  AACAACCAGACCATTACCGACCAAATCTACCGGGCAATGAACTCTTCGTCCTTTGAGGGT
  GTCTCTGGCCATGTGGTGTTTGATGCCAGCGGCTCTCGGATGGCATGGACGCTTATCGAG
  CAGCTTCAGGGTGGCAGCTACAAGAAGATTGGCTACTATGACAGCACCAAGGATGATCTT
  TCCTGGTCCAAAACAGATAAATGGATTGGAGGGTCCCCCCCAGCTGACCAGACCCTGGTC
  ATCAAGACATTCCGCTTCCTGTCACAGAAACTCTTTATCTCCGTCTCAGTTCTCTCCAGC
  CTGGGCATTGTCCTAGCTGTTGTCTGTCTGTCCTTTAACATCTACAACTCACATGTCCGT
  TATATCCAGAACTCACAGCCCAACCTGAACAACCTGACTGCTGTGGGCTGCTCACTGGCT
  TTAGCTGCTGTCTTCCCCCTGGGGCTCGATGGTTACCACATTGGGAGGAACCAGTTTCCT
  TTCGTCTGCCAGGCCCGCCTCTGGCTCCTGGGCCTGGGCTTTAGTCTGGGCTACGGTTCC
  ATGTTCACCAAGATTTGGTGGGTCCACACGGTCTTCACAAAGAAGGAAGAAAAGAAGGAG
  TGGAGGAAGACTCTGGAACCCTGGAAGCTGTATGCCACAGTGGGCCTGCTGGTGGGCATG
  GATGTCCTCACTCTCGCCATCTGGCAGATCGTGGACCCTCTGCACCGGACCATTGAGACA
  TTTGCCAAGGAGGAACCTAAGGAAGATATTGACGTCTCTATTCTGCCCCAGCTGGAGCAT
  TGCAGCTCCAGGAAGATGAATACATGGCTTGGCATTTTCTATGGTTACAAGGGGCTGCTG
  CTGCTGCTGGGAATCTTCCTTGCTTATGAGACCAAGAGTGTGTCCACTGAGAAGATCAAT
  GATCACCGGGCTGTGGGCATGGCTATCTACAATGTGGCAGTCCTGTGCCTCATCACTGCT
  CCTGTCACCATGATTCTGTCCAGCCAGCAGGATGCAGCCTTTGCCTTTGCCTCTCTTGCC
  ATAGTTTTCTCCTCCTATATCACTCTTGTTGTGCTCTTTGTGCCCAAGATGCGCAGGCTG
  ATCACCCGAGGGGAATGGCAGTCGGAGGCGCAGGACACCATGAAGACAGGGTCATCGACC
  AACAACAACGAGGAGGAGAAGTCCCGGCTGTTGGAGAAGGAGAACCGTGAACTGGAAAAG
  ATCATTGCTGAGAAAGAGGAGCGTGTCTCTGAACTGCGCCATCAACTCCAGTCTCGGCAG
  CAGCTCCGCTCCCGGCGCCACCCACCGACACCCCCAGAACCCTCTGGGGGCCTGCCCAGG
  GGACCCCCTGAGCCCCCCGACCGGCTTAGCTGTGATGGGAGTCGAGTGCATTTGCTTTAT
  AAGTGA
  
  Clone variation with respect to NM_001470.2
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001470 unedited
  TGTCAAATTTTGTATACGACTCACTATAGGCGGCCGCGATTCGGCACGAGGCCGGGCCTG
  GGGCTTTGAGGCCCGGGGAGAGCCGGGGAGCCGGGCCCGCGCGCCGAGATGTTGCTGCTG
  CTGCTACTGGCGCCACTCTTCCTCCGCCCCCCGGGCGCGGGCGGGGCGCAGACCCCCAAC
  GCCACCTCAGAAGGTTGCCAGATCATACACCCGCCCTGGGAAGGGGGCATCAGGTACCGG
  GGCCTGACTCGGGACCAGGTGAAGGCTATCAACTTCCTGCCAGTGGACTATGAGATTGAG
  TATGTGTGCCGGGGGGAGCGCGAGGTGGTGGGGCCCAAGGTCCGCAAGTGCCTGGCCAAC
  GGCTCCTGGACAGATATGGACACACCCAGCCGCTGTGTCCGAATCTGCTCCAAGTCTTAT
  TTGACCCTGGAAAATGGGAAGGTTTTCCTGACGGGTGGGGACCTCCCAGCTCTGGACGGA
  GCCCGGGTGGATTTCCGGTGTGACCCCGACTTCCATCTGGTGGGCAGCTCCCGGAGCATC
  TGTAGTCAGGGCCAGTGGAGCACCCCCAAGCCCCACTGCCAGGTGAATCGAACGCCACAC
  TCAGAACGGCGCGCAGTGTACATCGGGGCACTGTTTCCCATGAGCGGGGGCTGGCCAGGG
  GGCCAGGCCTGCCAGCCCGCGGTGGAGATGGCGCTGGAGGACGTGAATAGCCGCAGGGAC
  ATCCTGCCGGACTATGAGCTCAAGCTCATCCACCACGACAGCAAGTGTGATCCAGGCCAA
  GCCACCAAGTACCTATATGAGCTGCTCTACACGACCCTATCAGNACATCCTTATGCCTGG
  CTGCAGCTCTGTCTTCACGCTGGTGGCTGAGGCTGCTANGATGTGGACCCTCATGTGCNT
  TNCTATGGCTCAGCTACCAGCCTGTCAAACGCNAGCGTTCCACTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001470 unedited
  CCGCAAATCGGGTTGCNTTACTGCCNTAATTGNGGATCGGGGNGNATCCTTCCCCAGTAC
  CACCACAGTGTGTTAGGGACACCACCTCCCACCCCATAGGTCCATCTGTCTATCCCAACA
  GTCAAGGGTGCCTTCCTTTGGTCAGGATTCTCATCAACTATCCACTGGAAGCAGCTCTCC
  AAACCTGCCCCCACTTATTTTTCCTTAATTCCCCTCAAAAAAACACATATCAAAAGGGAG
  CAGTCTTGGGAGAAGATGATTGTGAGTGTAGACTGAGGGTAGTACATGAATGCAATGGAG
  ATGGGGGGAATCTGAGCAGAAATGGAGATTCTGTGACAAGGAGAGGGTGTGGATGGCCCC
  ACCAAACATGAATTGGGGAAAAGTGCATAACAATGTGCAGGGTAGGGTACATATGGCTCT
  GTCAGAAGAATACCATGATTTAAGGGAAGAAAGTACACAAGGTACATGGAGGGTACACAG
  GGAAAGTACATGGATAAACATGGACGTGTGCAAATAGGAAAGACATGACTCAGCATGCTA
  GACAAATTGCACATGCCTACCCAAACACGCTCAAGGGCAGACCCATGACCATGAGAGGGG
  CACACGTAGCTGTGAATGCAGGGCACCCGAGAGCACATGTGACTGAACATGAAGAAAGCA
  TACGGGAAAAGCGTGTGTACACATGAGCATGTTCAGTGGGCACACGCAGGAGAGGGGAGG
  ATGCATGTGTGCTGAGCGTGAGTGCACAGAGCAGAGGCAAGGAGCATGTGAGCCTTGGCG
  AAAAGATGAGCNTCCCAAGGAAGCAAATTCAGGTGAGCCCATGTGAGAAGTATGGAGGTN
  CAGTAGATGGAAGAGATATGACAGTGGAGAAAGGAAGGCCCTTTGGGTGGAAGAGCACTG
  TTGGAGACCCTGCTGGACAGACAGN
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001470
• Insert Size: 5130 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001470.1, NP_001461.1
• RefSeq Size: 4445 bp
• RefSeq ORF: 2886 bp
• Locus ID: 2550
• UniProt ID: Q9UBS5
• Cytogenetics: 6p22.1
• Domains: 7tm_3, CCP, ANF_receptor
• Protein Families: Druggable Genome, GPCR, Secreted Protein, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction
• Gene Summary: This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016]
  Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).