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Cenpe (NM_173762) Mouse Tagged ORF Clone
CAT#: MG219176
- TrueORF®
Cenpe (tGFP-tagged) - Mouse centromere protein E (Cenpe), (10ug)
ORF Plasmid: DDK
"NM_173762" in other vectors (2)
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Other products for "Cenpe"
Specifications
| Product Data | |
| Type | Mouse Tagged ORF Clone |
| Tag | TurboGFP |
| Symbol | Cenpe |
| Synonyms | 312kDa; AU019344; BC049989; C530022J18; CENP-E; Kif10 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MG219176 representing NM_173762
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCCGAGGAGGCTTCAGTGGCTGTCTGTGTTCGTGTGCGACCCCTCAACAGCAGAGAAGAAGAACTTG GAGAAGCCACCCACATTTACTGGAAAACAGATAAAAACGCTATTTATCAGAGCGATGGGGGTAAATCTTT CCAATTTGATCGTGTCTTTGACAGTAATGAAACCACGAAGAATGTGTATGAAGAGATTGCGGTGCCCATC ATCAGCTCCGCCATACAAGGCTACAATGGTACTATATTTGCCTATGGACAAACTGCATCAGGAAAGACAC ACACGATGATGGGTTCTGAAGATTGTTTGGGAGTTATACCCAGGGCAATTCATGACATTTTCCAAAGGAT AAAGAAGTTTCCTGAGAGAGAATTTCTCCTACGAGTTTCTTACATGGAGATCTACAATGAAACCATTACA GATTTACTCTGTAATGCTCAAAAAATGAAACCTTTGATAATTCGGGAAGACACCAATAGGACTGTATATG TTTCTGATCTCACAGAAGAAGTGGTTTATACAGCAGAAATGGCTTTGAAATGGCTCGCAACAGGAGAAAA AAACAGACATTATGGAATAACCAAAATGAATCAAAGAAGCAGTCGTTCTCATACGATTTTTAGGATGATT CTGGAAAGTAGAGAAAAGGCTGAGCCTTCTAACTGCGATGGCTCCGTCAAAGTGTCTCATCTGAATTTGG TCGATCTTGCAGGCAGTGAAAGAGCTGCTCAAACAGGAGCTGAAGGTGTGCGATTGAAGGAGGGCTGTTT TATAAATCGGAACTTGTTTATTTTGGGACAAGTGATTAAGAAACTCAGTGATGGACAGGTTGGGGGTTTC ATAAATTACCGAGATAGCAAATTGACACGAATTCTTCAGAATTCCTTGGGAGGAAATGCCAAGACGCGCA TCATCTGCACGATCACCCCAGCGTCCCTGGACGAAACCCTGACGACGCTGCAGTTTGCCAGCACTGCTAA GTATATGAAGAATACTCCTTACGTTAATGAAGTGTCGAATGATGAAGCTCTCTTGAAAAGATACAGAAGA GAAATAGCGGATCTTAGAAAACAATTAGAGGAGGTAAATACAAAGACTCGGGCACAGGAAATGGAAAAGG ATCAACTGGCCCAGCTTCTGGATGAAAAAGACTTGCTTCAGAAAGTTCAGGATGAGAAAATTAATAACCT GAAGCGGATGCTGGTGACGTCATCTTCTATTGCATTGCAGCAGGAGCTAGAGATTAAAAGGAAACGAAGA GTTACTTGGTGCTATGGCAAAATGAAGGATTCAAACTATGAAAAGGAATTTAAAGTCCCGACAAGCATAA CAACAAGAAAACGTAAAACTTCTGTGACTTCTTTGAGAGAAAATTCTCTCATGAAGTTCGGAGAGAGTGC AGCCTCTTCCGAGTTTGAAATGTTGAATAACACTCTTGAGTCATTGGCTGAGGTAGAGTGGAGCTCGGCA ACAACGCTCCTAAGCGAGGAAAATGTAGAAAGTGAGTTGAACTCACTTAATGCTCAATATAATGATCTGG TATTAGACTATGAACAGCTCAGAAGAGAAAATGAAGACTTGAAATTGAAATTAAAAGAAAAAAATGAGTT AGAGGAATTTGAGCTTCTAGAACAAAAAGAAGAAAGAGATCAAGAGATGCAACTAATGCATGAAGTTTCC AACTTAAAGAATTTAATTAAACACGCAGAAGAATATAATCAAGACCTTGAGAATGACCTAAGTTCAAAAG TGAAGCTTCTTAAAGAAAAAGAGGAGCAGATTAAGAACCTGCAGGAATACATAGATGCCCAGAAGTCAGA AAAGATGAAGATAGACCTGTCATACACATCGGACGCCACTGAAGACCTGAAACAGGCGATGCGCACCCTG TCTGATTTGGACACAGTGGCCCTTGACGCTAAGAAAGAGTCAGCCTTCCTTAGAAGTGAAAATCTGGAGC TGAAGGAGAAAATTAATGAACTTTCGGATTCCCGTAAGCAAATGGAAAGTGACATTCAGATGTATCAACG CCAACTGGAAGCAAAAAAGAAAATGCAAACTGATCTGGATAAGGAATTACAGTTGGCTTTTCAAGAAATA TCAAAACTCAGCGCCCTGGTAGATGGCAAAGGTTTACTGTCTAATTTGGAATTGGAGAAAAGGATTACTG ATCTCCAAAAAGAACTAAATAAAGAAGCTGAAGAAAAACAAACTTTGCAAGAAGAAGTTAACTTGCTGTC GGAGTTGAAATCTTTACCGTCTGAGGTGGAAACGCTGAGGAGAGAGCTGTATGAGAAATCTGAAGAGCTC CATATAATAACCACAGAAAGAGAGAAACTGTTTTCTGAAATGGCTCATAAAGACAGTAGGATTCAAGGTT TACTTGAGGAAATTGGAAACACTAGAGATGACCTTGCCACTTCCCAGCTGAGTCGGAGGGGCAGTGATGG AGAATGGCAAGCCCTGGAAAGCCTGCACGCAGAGCTGGAGCACAGACACGCGGGGGTCCTGGAGGAGAGA GAGAGGCTGAAGCAGGAGATTGGGGCTCTCTCCAAAGAAGCAGAAAGCCTGGCTTTCAGTTTGGATTCCG TGAAGGCCGAGCTTTCTCACAAGACTCAAGAGCTTGAGCAGAAAACAGTTGAGGGTCAAGAAAGGCTAAA TAAAATGGAGGCGCTGAGAGAAGAGTTAGAAAGCAGAGACTCCAGCCTGCAGTCTGTAGAGAAGGAGAAA GTCCTGCTCACTGAGAAGCTGCAGCAAGCCTTGAAGGAAGTAAAAGCCTTAACCCAAGAAAAGAAAAACC TGAAGCAGCTCCAGGAGAGCCTGCAAACTGAGAGAGACCAACTCAGAAGTGACATTCAGGACACTGTGAA CATGAACATAGATACTCAAGAGCAGTTACTAAATGCTCTGGAGTCTCTGAAACAACACCAAGAAACAATT AACATGCTGAAAATGAAAGCTGCTGAGGAACTATCCGATAATTTGCATGTAAAGGACAGGGGAGGAGCTA GAGATGAAGCTCAGCAAAAGATGGATGGCATAGATGAACAGAATGAGAGTGCCCACACATTGCTTGGTGG TGGTAAGGACAATGAGGTAACTGAGGAACAGAGGAAAATCGACTCTCTAATGCAGGAGAATAGCGGACTC CAACAGACACTGGAAAGTGTTAGAGCAGAAAAGGAACAACTGAAGATGGACCTAAAGGAAAATATCGAAA TGAGTATTGAAAACCAGGAAGAGTTAAGAATTCTTAGAGATGAACTGAAAAGACAACAAGAGGTAGCTGC ACAGGAAAAGGATCATGCCACCGAGAAGACCCAGGAGCTCTCCAGGACGCAGGAAAGATTGGCAAAAACA GAAGAGAAGTTAGAGGAAAAGAACCAGAAACTCCAAGAGACACAGCAGCAACTTCTTAGTACACAAGAAG CTATGAGTAAGCTGCAGGCAAAGGTGATTGACATGGAAAGCTTACAGAATGAATTCAGGAACCAAGGATT GGCATTGGAGCGTGTGGAGACAGAGAAACTGGAGTTAGCTCAGAGACTTCATGAAAGTTATGAGGAGGTG AAATCTATAACCAAAGAAAGAAATGATCTAAAGGAATTGCAGGAGTCATTTGAAATAGAGAAGAAGCAAC TTAAAGAATATGCAAGGGAAATAGAAGCCGCGGGCCTACAAACAAAAGAAGAACTAAACATTGCCCACGC GAATCTAAAAGAGTACCAGGAAATCATCACAGAGCTAAGAGGAAGCATTTCTGAAAACGAAGCACAAGGA GCAAGCACCCAGGACACGGCAAAAAGCGCCCCTGAGCTACAAGGAGAGGTTCCAGAGCAAGAGCTGCTTC CTGTTGTCAAAGAAGCCAGGCACAGTGCAGAAAAAGTGAACGGACTGGAGCCAGTGGGAGCACATTCCAG AACAGTGCACTCCATGACAATGGAGGGCATAGAAATAGAAAACCTCAGGCTGACCAAGAAACTTGAAGAA AGTCAGATGGAGATCAGCTGTCTCACTAGAGAGAGAGAAGACCTGAGAAGGACACAGGAAACACTTCAGG TCGAATGTACCCAGCTGAAAGAAGATGCCAGAAGAACTTTGGCTAATCATCTAGAAACTGAAGAGGAACT TAACCTTGCTCGTTGTTGCCTGAAAGAGCAGGAGAACAAGATTGACACCCTAATAACGAGCCTCTCGCAG AGGGAAACTGAGCTGTCCAGTGTGCGAGGACAACTAGCGCTGACTACTGCTGAACTGGAGAGAAAGGTTC AAGAACTCTGTGAGAAACAGGAAGAACTTACTAGGAAAGAAACTAGCGAGGCTCAAGGGAAGATGAGTGA ACTAGAGCAACTCAGGGAGCTGCTGCTTGCCCAGGCCTCGGCACTGCAGAACGCAGAGAGTGACAGGCTG CGGCTGAATACACAACTGGAAGAAAGTCAAGAGGAAATGAAAACTCTAAGGGAGGAAAGAGAAGAGCTGA GAAGAATGCAAGAGGCTCTTCACGTGGAAAGTGAGCAGCAGAAAGAAAGCATGAAGGAAATCAGCTCAAA ACTCCAAGAACTACAGAACAAAGAGTATGAATGTCTTGCAATGAAGACTATTAATGAGACTCAAGGAAGC AGATGTGAAATGGACCACTTGAACCAGCAGCTGGAGGCCCAGAAGTCAACTCTGGAAAAGGTGGAGATGG AGAATGTAAACTTGACTCAAAGACTTCATGAGACCCTTGAGGAAATGAGATCTGTAGCAAAAGAAAGAGA TGAGCTTTGGAGCATGGAGGAGCGCCTCACAGTAGAGAGAGACCAACTGAAGAAGAGCCTTGAAGAAACA GTAACTAAAGGTATGGAAAAAGAGGAAGAGCTAAGAGTTGCGCATGTGCATCTGGAAGAGCACCAGGAAA CTATCAACAAGCTCAGAAAGATGGTGTCTGACTACACAGATGAAATATCACATACTCAAGGGGACCTAAA GCACACAAATGCCGTTGTAGAAGCTCAGAACCAAGATCTCCGGGAAAAAGAACATCAACTTTCTCAAGTA AAAGCTGATCTCAGAGAAACCGTGGATCAAATGGAGCAACTGAAGAAGAAGCTCGAAGCCCAGAGTTCGA CTCTAGAAAGCAGAGAAATAGAGAAGTTAGAATTGACTCAGCAACTTAACGAAAACCTTAAAAAAATAAC ACTTGTCACTAAGGAAAATGATAGCCTAAAAATTATGGATGAAGCCCTCAGGGAAGAACGAGACCAGCTA CGGAAAAGTCTTCAGCAAACAGAGGCAAGGGATCTGGAAAATCAAGAGAAACTAAGAATTGCTCACATGA ATCTAAAAGAGCACCAAGAAACTATTGACCGACTCATGGAGACTATGTCTGAGAAGACAGAGGAAATATC AAATATGAAAATGGAGTTAGAAAATGTAAACATGAAATTACAAGAAAAGGTTCAAGAACTTAAGACAAGT GAGCGTCAACGTGTTAAGTTAAAAGCAGATGCCAGTGAAGCCAAGAAGGAGCTCAAGGAGCAGGGCTTAA CTCTGAGTAAGATAGAGATGGAGAACTTAAATCTCGCTCAGAAGATTCATGAGAACCTTGAAGAAATGAA ATCTGTAAGAAAAGAAAGAGATGATCTAAAGAAACTTGAGGAGATACTCAGAATGGAGAGAGACCAGCTC AAGGACAACCTGAGAGAAGCCATGCTTAAGGCCCACCAGAACCATGAAGAGACAATGAAATGTGGAAAGG GGTTACTGTGTGCTGGAGAATACTGTACAGGAAGACTTCGAGAAAAGTGCTTCAGGATAGAAAAACTCCT GAAAAGATACTCAGAAATGGCTAATGATTATGAGTGCTTGAATAAAGTCTCTCTTGACTTGGAGAGAGAA ACTAAAACCCAAAAAGAGCTGTCAGTTACTGTAAGAACAAAGCTCTCACTTCCGCACACACAGACCAAAG AGATGGAAAAGCTTCTGACTGCAAACCAGAGATGTTCCCTGGAGTTCCACAGAGCCCTCAAGAGACTTAA GTACGTGTTAAGCTCCATTGCGAGGATAAAGGAAGAGCAGCATGAGTCCATCAATAAACGTGAAATGGCT TTTATTCAGGAAGTGGAAAAGCAGAATGAACTGCAGATTCAAATCCAGAGCCTTTCACAGACTTACCGTA TTCCAGCCAGAGACTTACAGATCAAACTGAGCCAGGAGATGGACCTCCATATTGAGGAAATGCTCAAAGA TTTTTCAGAAAATGATTTCCTCACCATAAAAACTGAAGTCCAACAAGTATTAAATAATAGGAAAGAAATA ACTGAGTTTTTGGGAAAATGGCTAAATACTCTTTTTGATACAGAAAATCTTAAGAGCACCATCCAGAAAG AAAACAAAAGCATTGGGCTCGTGAATAACTTCTATCACAGCAGAATCACTGCCATGATAAATGAATCAAC GGAGTTTGAGGAAAGAAGTGCTACCAGATCCAAAGACTTGGATCAGTACCTGAAGTCACTGAAAGAAACA ACTGAGCAACTGTCTGAAGTCTACCAGACACTGACCGCCTCCCAGTCTGTTGTGCATCTCCATCCTACCG TGCAGCCTTCCACACGGGACAGTGAGCGTCCTCAGGCTGCATCAGGAGCTGAACAACTGACCTCAAAGAA CAAAATTGCTTTAGGAGCTGTGCCCTATAAAGAAGAAATTGAGGATCTCAAAATGCAGCTGGTGAAGAGT GACCTAGAGAAGAAGGCGACCGCCAAGGAATTCGATAAGAAAATTCTCTCTCTAAAAGCCACTGTTGAAC ATCAAGAAGAAATGATAAGGCTACTGAGAGAAAATCTTAGAGGACATCAACAGGCCCAGGATACCTCAAT GATCTCAGAACAAGACTCTCAGCTTCTGAGTAAACCTCTAACCTGTGGAGGTGGCAGTGGAATTGTACAA AGCACAAAAGCTCTTATTTTGAAAAGTGAATATAAAAGGATGGGAAGTGAGATTTCTAAGTTAAAGCAGC AAAATGAGCAGCTAAGAAAGCAAAATAATCAACTATTAAGTGATAACTCTCAACTCTCCAATGAGGTTAA AACCTGGGAGGAAAGAACTCTTAAAAGAGACAGTTACAGAGAAACAACTTGTGAGAATTCTCCAAAGTCT CCTAAAGTGACTCGGACAGATTCTAAAAGGAGACAGAACACAACTTCTCAGTGCAGGGCACAAAATCTCC AGGATCCTGTGCCAAAAGATTCCCCAAAATCATGGTTTTTTGATAACCGGTCAAAGTCTCTTCCAGCACC TCACCCGATCCGCTATTTTGACAACTCCAGTCTAGGGCTGTGCCCAGAACCAGATGACGTAGAGAATGTG GAGCCTAAGACAGACCTCTGCCAAGCCTCCTTGGAAAAAGATGTGTCCCAGTGCAAGACGCAG ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAA >MG219176 representing NM_173762
Red=Cloning site Green=Tags(s) MAEEASVAVCVRVRPLNSREEELGEATHIYWKTDKNAIYQSDGGKSFQFDRVFDSNETTKNVYEEIAVPI ISSAIQGYNGTIFAYGQTASGKTHTMMGSEDCLGVIPRAIHDIFQRIKKFPEREFLLRVSYMEIYNETIT DLLCNAQKMKPLIIREDTNRTVYVSDLTEEVVYTAEMALKWLATGEKNRHYGITKMNQRSSRSHTIFRMI LESREKAEPSNCDGSVKVSHLNLVDLAGSERAAQTGAEGVRLKEGCFINRNLFILGQVIKKLSDGQVGGF INYRDSKLTRILQNSLGGNAKTRIICTITPASLDETLTTLQFASTAKYMKNTPYVNEVSNDEALLKRYRR EIADLRKQLEEVNTKTRAQEMEKDQLAQLLDEKDLLQKVQDEKINNLKRMLVTSSSIALQQELEIKRKRR VTWCYGKMKDSNYEKEFKVPTSITTRKRKTSVTSLRENSLMKFGESAASSEFEMLNNTLESLAEVEWSSA TTLLSEENVESELNSLNAQYNDLVLDYEQLRRENEDLKLKLKEKNELEEFELLEQKEERDQEMQLMHEVS NLKNLIKHAEEYNQDLENDLSSKVKLLKEKEEQIKNLQEYIDAQKSEKMKIDLSYTSDATEDLKQAMRTL SDLDTVALDAKKESAFLRSENLELKEKINELSDSRKQMESDIQMYQRQLEAKKKMQTDLDKELQLAFQEI SKLSALVDGKGLLSNLELEKRITDLQKELNKEAEEKQTLQEEVNLLSELKSLPSEVETLRRELYEKSEEL HIITTEREKLFSEMAHKDSRIQGLLEEIGNTRDDLATSQLSRRGSDGEWQALESLHAELEHRHAGVLEER ERLKQEIGALSKEAESLAFSLDSVKAELSHKTQELEQKTVEGQERLNKMEALREELESRDSSLQSVEKEK VLLTEKLQQALKEVKALTQEKKNLKQLQESLQTERDQLRSDIQDTVNMNIDTQEQLLNALESLKQHQETI NMLKMKAAEELSDNLHVKDRGGARDEAQQKMDGIDEQNESAHTLLGGGKDNEVTEEQRKIDSLMQENSGL QQTLESVRAEKEQLKMDLKENIEMSIENQEELRILRDELKRQQEVAAQEKDHATEKTQELSRTQERLAKT EEKLEEKNQKLQETQQQLLSTQEAMSKLQAKVIDMESLQNEFRNQGLALERVETEKLELAQRLHESYEEV KSITKERNDLKELQESFEIEKKQLKEYAREIEAAGLQTKEELNIAHANLKEYQEIITELRGSISENEAQG ASTQDTAKSAPELQGEVPEQELLPVVKEARHSAEKVNGLEPVGAHSRTVHSMTMEGIEIENLRLTKKLEE SQMEISCLTREREDLRRTQETLQVECTQLKEDARRTLANHLETEEELNLARCCLKEQENKIDTLITSLSQ RETELSSVRGQLALTTAELERKVQELCEKQEELTRKETSEAQGKMSELEQLRELLLAQASALQNAESDRL RLNTQLEESQEEMKTLREEREELRRMQEALHVESEQQKESMKEISSKLQELQNKEYECLAMKTINETQGS RCEMDHLNQQLEAQKSTLEKVEMENVNLTQRLHETLEEMRSVAKERDELWSMEERLTVERDQLKKSLEET VTKGMEKEEELRVAHVHLEEHQETINKLRKMVSDYTDEISHTQGDLKHTNAVVEAQNQDLREKEHQLSQV KADLRETVDQMEQLKKKLEAQSSTLESREIEKLELTQQLNENLKKITLVTKENDSLKIMDEALREERDQL RKSLQQTEARDLENQEKLRIAHMNLKEHQETIDRLMETMSEKTEEISNMKMELENVNMKLQEKVQELKTS ERQRVKLKADASEAKKELKEQGLTLSKIEMENLNLAQKIHENLEEMKSVRKERDDLKKLEEILRMERDQL KDNLREAMLKAHQNHEETMKCGKGLLCAGEYCTGRLREKCFRIEKLLKRYSEMANDYECLNKVSLDLERE TKTQKELSVTVRTKLSLPHTQTKEMEKLLTANQRCSLEFHRALKRLKYVLSSIARIKEEQHESINKREMA FIQEVEKQNELQIQIQSLSQTYRIPARDLQIKLSQEMDLHIEEMLKDFSENDFLTIKTEVQQVLNNRKEI TEFLGKWLNTLFDTENLKSTIQKENKSIGLVNNFYHSRITAMINESTEFEERSATRSKDLDQYLKSLKET TEQLSEVYQTLTASQSVVHLHPTVQPSTRDSERPQAASGAEQLTSKNKIALGAVPYKEEIEDLKMQLVKS DLEKKATAKEFDKKILSLKATVEHQEEMIRLLRENLRGHQQAQDTSMISEQDSQLLSKPLTCGGGSGIVQ STKALILKSEYKRMGSEISKLKQQNEQLRKQNNQLLSDNSQLSNEVKTWEERTLKRDSYRETTCENSPKS PKVTRTDSKRRQNTTSQCRAQNLQDPVPKDSPKSWFFDNRSKSLPAPHPIRYFDNSSLGLCPEPDDVENV EPKTDLCQASLEKDVSQCKTQ TRTRPLE - GFP Tag - V |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_173762 |
| ORF Size | 7413 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_173762.4, NP_776123.3 |
| RefSeq Size | 7813 bp |
| RefSeq ORF | 7416 bp |
| Locus ID | 229841 |
| UniProt ID | Q6RT24 |
| Cytogenetics | 3 62.55 cM |
| Gene Summary | Microtubule plus-end-directed kinetochore motor which plays an important role in chromosome congression, microtubule-kinetochore conjugation and spindle assembly checkpoint activation. Drives chromosome congression (alignment of chromosomes at the spindle equator resulting in the formation of the metaphase plate) by mediating the lateral sliding of polar chromosomes along spindle microtubules towards the spindle equator and by aiding the establishment and maintenance of connections between kinetochores and spindle microtubules. The transport of pole-proximal chromosomes towards the spindle equator is favored by microtubule tracks that are detyrosinated. Acts as a processive bi-directional tracker of dynamic microtubule tips; after chromosomes have congressed, continues to play an active role at kinetochores, enhancing their links with dynamic microtubule ends. Suppresses chromosome congression in NDC80-depleted cells and contributes positively to congression only when microtubules are stabilized (By similarity). Plays an important role in the formation of stable attachments between kinetochores and spindle microtubules (PubMed:12925705). The stabilization of kinetochore-microtubule attachment also requires CENPE-dependent localization of other proteins to the kinetochore including BUB1B, MAD1 and MAD2. Plays a role in spindle assembly checkpoint activation (SAC) via its interaction with BUB1B resulting in the activation of its kinase activity, which is important for activating SAC (PubMed:12361599). Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss (PubMed:12925705).[UniProtKB/Swiss-Prot Function] |
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