Psmd14 (BC003742) Mouse Untagged Clone

CAT#: MC206468

Psmd14 (untagged) - Mouse proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 (cDNA clone MGC:5840 IMAGE:3599671), complete, (10ug)


Reconstitution Protocol

USD 300.00

In Stock*

Size
    • 10 ug

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Specifications

Product Data
Type Mouse Untagged Clone
Tag Tag Free
Symbol Psmd14
Synonyms Poh1, Pad1, rpm11
Vector PCMV6-Kan/Neo
E. coli Selection Kanamycin (25 ug/mL)
Mammalian Cell Selection Neomycin
Sequence Data
>BC003742
CGGGCTGATTCATCGCCTGTTCTCCGAGCCAGGTCCTTGTTGAGTGTGAGGCGCTGCCCTCGCCGCCGCG TCGCCACAAGGCCAGGAGAGAGAGGAAAAACTACTTGTGAAAAATTGTATCTGCCAGAATTAGCAAGACT TGGAGTTAATAACAAATTTGTCAAATTCAACAAATTGAAGTTTAACACTGTAAGAATTACAGTTACTGAA CAGAAATATGGACAGACTTCTTAGACTTGGAGGAGGTATGCCTGGACTGGGCCAGGGCCCACCTACAGAT GCTCCTGCCGTGGACACAGCAGAACAAGTTTATATCTCTTCCTTGGCCTTGCTAAAGATGTTAAAACATG GTCGTGCTGGAGTGCCTATGGAAGTTATGGGTCTAATGCTTGGTGAATTTGTTGATGATTACACCGTCAG AGTGATTGATGTGTTTGCTATGCCACAGTCAGGAACTGGTGTCAGTGTTGAAGCAGTTGATCCAGTGTTC CAAGCCAAAATGTTGGATATGCTGAAACAAACAGGAAGGCCCGAGATGGTTGTTGGTTGGTATCACAGTC ACCCTGGCTTTGGCTGTTGGCTTTCTGGTGTGGATATCAACACTCAGCAGAGCTTTGAAGCCTTGTCGGA GAGAGCTGTGGCAGTGGTTGTGGATCCCATTCAGAGTGTAAAAGGAAAGGTTGTTATTGATGCCTTCAGA CTGATCAATGCTAATATGATGGTCTTAGGACATGAACCAAGACAAACGACTTCAAATCTGGGCCACTTAA ACAAGCCATCTATCCAGGCATTAATTCACGGACTAAACAGACATTATTACTCCATCACTATTAATTACCG GAAAAATGAACTGGAACAGAAGATGCTGTTAAATTTGCATAAGAAGAGTTGGATGGAAGGATTGACACTT CAGGACTACAGTGAACACTGTAAACACAATGAATCGGTGGTAAAAGAAATGTTGGAATTAGCCAAGAATT ATAATAAGGCTGTGGAAGAAGAAGATAAGATGACACCTGAACAGCTGGCAATAAAGAATGTTGGCAAGCA GGATCCCAAACGTCATTTGGAAGAACATGTGGATGTGCTTATGACTTCAAATATTGTCCAGTGTTTGGCC GCAATGTTGGATACTGTTGTATTTAAATAAAGTGACGTAGAGAGCTGTCAGTGGCGCTCTGAGTGTATCG TCCTTCTTCGTTCCCAATGCTCACAGTTAAGGGAACTGAAGGTGATCTGGTGATGTGTGAGACACCTGTG CCACCTCCCATCTCAGTTGTGCACTCGCTTCTGTTTATTTTGTCCGGGTTTTGCAGATTCCAAAGTTGTT CAGGAATACATCAAAGTGAACAAATTTTGTTAAGATCCCATTTACTATTTGAAAAAAATCAGTAGCACAA ATATATTTTGATTGTTGCTTACAAAATAAAATACATTTACAATCCAAAAAAAAAAAAAAA
Restriction Sites EcoRI-NotI     
ACCN BC003742
Insert Size 933 bp
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq BC003742, AAH03742
RefSeq Size 1460 bp
RefSeq ORF 933 bp
Locus ID 59029
Cytogenetics 2 C1.3
Gene Summary Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. The PSMD14 subunit is a metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains within the complex. Plays a role in response to double-strand breaks (DSBs): acts as a regulator of non-homologous end joining (NHEJ) by cleaving 'Lys-63'-linked polyubiquitin, thereby promoting retention of JMJD2A/KDM4A on chromatin and restricting TP53BP1 accumulation. Also involved in homologous recombination repair by promoting RAD51 loading.[UniProtKB/Swiss-Prot Function]

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