Txnip (BC011212) Mouse Untagged Clone

CAT#: MC201032

Txnip (untagged) - Mouse thioredoxin interacting protein (cDNA clone MGC:18703 IMAGE:4193517), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Txnip
• Synonyms: THIF, VDUP1, mVDUP1
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC011212
  GATTTCCAGAGTTTCTCCAGTTGCGGAAGACAGCTGTTATTTTTCTCCTGAAAGCTCTTGGCACAGCCGG CAGGTTGAAACTTTCAGGCACCTTTTGGAAAAGTTGTTAGGGTTTGTTTGAAGCTTTCTTTACATTTTCG TTTGGGTTTTCAAGCCCTGACTTTACGGAGGTGAGCTCTTCGTTTGCTTTGAAGGGTTCTTAAAGATTTT TTTCCTCTCCGGCTTTCGTTTTTCTTGAACCCACTCGGCTCAATCATGGTGATGTTCAAGAAGATCAAGT CTTTTGAGGTGGTCTTCAACGACCCCGAGAAAGTGTACGGCAGCGGGGAGAAGGTGGCCGGACGGGTAAT TGTGGAAGTGTGTGAAGTTACCCGAGTCAAAGCTGTCAGGATCCTGGCTTGCGGCGTGGCCAAGGTCCTG TGGATGCAAGGGTCTCAGCAGTGCAAACAGACTTTGGACTACTTGCGCTATGAAGACACACTTCTCCTAG AAGAGCAGCCTACAGCAGGTGAGAACGAGATGGTGATCATGAGGCCTGGAAACAAATATGAGTACAAGTT CGGCTTCGAGCTTCCTAGAGGGCCCCTGGGAACATCCTTTAAAGGAAAATATGGTTGCGTAGACTACTGG GTGAAGGCTTTTCTCGATCGCCCCAGCCAGCCAACTCAAGAGGCAAAGAAAAACTTCGAAGTGATGGATC TAGTGGATGTCAATACCCCTGACTTAATGGCACCAGTGTCTGCCAAAAAGGAGAAGAAAGTTTCCTGCAT GTTCATTCCTGATGGACGTGTGTCAGTCTCTGCTCGAATTGACCGAAAAGGATTCTGTGAAGGTGATGAC ATCTCCATCCATGCTGACTTTGAGAACACGTGTTCCCGAATCGTGGTCCCCAAAGCGGCTATTGTGGCCC GACACACTTACCTTGCCAATGGCCAGACCAAAGTGTTCACTCAGAAGCTGTCCTCGGTCAGAGGCAATCA CATTATCTCAGGGACTTGCGCATCGTGGCGTGGCAAGAGCCTCAGAGTGCAGAAGATCAGACCATCCATC CTGGGCTGCAACATCCTCAAAGTCGAATACTCCTTGCTGATCTACGTCAGTGTCCCTGGCTCCAAGAAAG TCATCCTTGATCTGCCCCTAGTGATTGGCAGCAGGTCTGGTCTGAGCAGCCGGACATCCAGCATGGCCAG CCGGACGAGCTCTGAGATGAGCTGGATAGACCTAAACATCCCAGATACCCCAGAAGCTCCTCCTTGCTAT ATGGACATCATTCCTGAAGATCACAGACTAGAGAGCCCCACCACCCCTCTGCTGGACGATGTGGACGACT CTCAAGACAGCCCTATCTTTATGTACGCCCCTGAGTTCCAGTTCATGCCCCCACCCACTTACACTGAGGT GGATCCGTGCGTCCTTAACAACAACAACAACAACAACAACAACAGCAACGTGCAGTGAGCCTGCAGGAAA TGAAGCATCTGTATTAGCGCATTTCTTTCTGCCTCTCTGCTTGAACTCCAGTGTTTCAGAGACTCAGTCT CTACAGCGGGGAACGGGTACACCCCAGCCGCTGACTCCTCAAGATGGGTGGCAATCAGTAGGCAGGTCTC CGGCTTCAAGTGGTGCAGACCAGTGCCCGCACTGTGGCAAAGGAGTGTTTGCTGGGTGGATGTCAGAACA GTCTAGAAAAATTGAGACCTGACCACTTTCTCGGATGTTGGAAATGAAGAACTTGTTTGTGTTGACTGAG TCAGGGCACTGCTGACCTTCTGGCGTTGTCTTTCCAAGGTTTTTGTTTTAAAGGGAATTTTAAATTGTCT AAAATACCAGTAGACCATCATCTGTGCCATGGGGGACAGAGCCAATTTCAAGTCATGGCCAAAATTTTGT AAGAGGAGTGTTTTTGTGTGTTTTTTAAAGTCAGTGTTCCTTTTTTATATCTTTACAAAGAAAAGACCTT CCACGGCTGGTGAGCACGCAGCCTGTGAAATTCGGGGCAGCTGCTCCAAGTTGACTTCACCCTGGGAGCA GTAGTAGCTGTGCCCACTGACGGCCATAAAAGCCATTTTACAGCCAGTTGCACTGTGTTCTCTTGTAAGC ATAATCAGATGGGAGAATCTGTTATTTCCCTGTAACCCCTTGGAATTGATTCTAAGGTGATGTTCTTAGC ACTTTAGCTTGTCAGTTTTGTTTTAGTCTCCGTTATAGATGTAAGCTCCACCAGTCTCTTAAGGGTTAAG CCCAGTGACTTGGAGGGTGGGGGTTAGGGTCTCTATCCCTGAACATTGTAGACCCAGGCTGGCCTGAGAG AGAGATCCACCTGCCTCTGCCTCCTGAGTGCTGCGATCAAAGGCCCAGCTTGGTTATTGCTTTTGAGGCT TTCTCCCAACGCACAGACTTGTATAATTCTAACACTAATCCTGTGAAGGGTTGTGGTTGACAGCTGGAGC CTGGGTGACATTCTACATTGAGATGCCCCAGCACTGATCGGGGCACAGAAGCCCCCAGACCCCATTTCCT GTCCAGTGTTGGGAGAAAGTGCTGCTTTCACTGTGGCCTCAGCCCTGGCTCGGAAGCTCACTAAGCCTTA GCACTTTGTCCTGTGTCAGCTCCACCTGAGAACTGTGCAGCCAGAATGTCTGCGAGCTGATGGAGGTTTC GGTTTTATTGTTTTTGTATTTTGTGTATCTTTTTGTATGATTAAAAACTATATTTTCTACTTATCCAAAT ATATTTTCACCCCAAAGTGGGGTTATCCTTTGTAAAAAAAATAAAGTTTTTTAATGACAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: BC011212
• Insert Size: 1203 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC011212, AAH11212
• RefSeq Size: 2799 bp
• RefSeq ORF: 1203 bp
• Locus ID: 56338
• Cytogenetics: 3 41.93 cM
• Gene Summary: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.[UniProtKB/Swiss-Prot Function]