BCL10 Mouse Monoclonal Antibody [Clone ID: OTI4A8]

CAT#: TA400004

Anti-BCL10 mouse mAb, clone OTI4A8, PE conjugated

Product Images

Jurkat T cells are fixed 2% formaldehyde for 20 min, then permeabilized with 0.1% saponin. The cells are then stained with a PE-labeled isotope control antibody, or 4A8 or 6A4 anti-Bcl10 antibodies.

Specifications

Product Data

• Clone Name: OTI4A8
• Applications: FC
• Recommended Dilution: FC 1:50
• Reactivities: Human
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Full length human recombinant protein of human BCL10 (NP_003912) produced in HEK293T cell.
• Formulation: PBS (pH7.4) containing 0.02% NaN3; store at 4C, do not freeze
• Concentration: 0.5 mg/ml
• Purification: Purified from mouse ascites fluids by affinity chromatography
• Conjugation: PE
• Storage: Store at 4°C.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 26.1 kDa
• Gene Name: BCL10 immune signaling adaptor
• Database Link:
  NP_003912
  Entrez Gene 8915 Human
  UniProt ID O95999
• Background: This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
• Synonyms: c-E10; CARMEN; CIPER; CLAP; IMD37; mE10

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: B cell receptor signaling pathway, T cell receptor signaling pathway