TIRAP Mouse Monoclonal Antibody [Clone ID: 20D1055.1]

CAT#: TA336468

Mouse Monoclonal Tirap Antibody (20D1055.1)

Product Images

Western Blot: TIRAP Antibody (20D1055.1) TA336468 - Analysis of TIRAP in human spleen lysate using this antibody.

Specifications

Product Data

• Clone Name: 20D1055.1
• Applications: WB
• Recommended Dilution: Western Blot: 1:500-1:1000
• Reactivities: Human
• Host: Mouse
• Isotype: IgM, kappa
• Clonality: Monoclonal
• Immunogen: This antibody was developed against a synthetic peptide corresponding to a portion of human TIRAP.
• Formulation: Preservative: 0.05% Sodium Azide. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Concentration: lot specific
• Purification: Ascites
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: toll-interleukin 1 receptor (TIR) domain containing adaptor protein
• Database Link:
  NP_001034750
  Entrez Gene 114609 Human
  UniProt ID P58753
• Background: The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). TIRAP (TIR domain-containing adaptor protein) is an adaptor protein used by TLR4. Blocking TIRAP inhibits TLR4-mediated signaling events, including DC maturation and cytokine production (4). It has 235 amino acids and is commonly seen as a 32-37 kD protein (4).
• Synonyms: BACTS1; Mal; MyD88-2; wyatt

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Toll-like receptor signaling pathway