PLK1 Mouse Monoclonal Antibody [Clone ID: 3F8]
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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
USD 200.00
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Specifications
Product Data | |
Clone Name | 3F8 |
Applications | WB |
Recommended Dilution | WB, IP, IF |
Reactivities | Human, Mouse |
Host | Mouse |
Isotype | IgG1, kappa |
Clonality | Monoclonal |
Immunogen | Amino Acid: 300-603 of human PLK-1 |
Formulation | This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml. |
Concentration | lot specific |
Purification | The antibody was purified by affinity chromatography. |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Predicted Protein Size | 68 kD |
Gene Name | polo like kinase 1 |
Database Link | |
Background | PLK-1 (polo-like kinase 1) is a member of te serine/threonine protein kinase family, cdc5/polo subfamily. Highly homologous to polo-like kinase (Drosophila), PLK-1 contains two polo box domains with a predicted molecular weight of 68 kD. This nuclear protein is highly expressed in placenta and colon and has been shown to regulate cdc2/cyclin B through phosphorylation and activation of cdc25c phosphatase. PLK-1 may also be required for cell division; depletion of PLK-1 results in apoptosis. PLK-1 is upregulated by growth stimulating agents and is regulated by cell cycle position (highest in G2/M phase, declining to nearly undetectable levels after mitosis and throughout G1). PLK-1 is modified by phosphorylation (Thr210 is the major phosphorylation site in activated PLK-1 from mitotic cells) and has been shown to interact with nuclear distribution gene C. The 3F8 monoclonal antibody recognizes human and mouse PLK-1 and has been shown to be useful for Western blotting. |
Synonyms | PLK; STPK13 |
Reference Data | |
Protein Families | Druggable Genome, Protein Kinase |
Protein Pathways | Cell cycle, Oocyte meiosis, Progesterone-mediated oocyte maturation |
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