ATP7B Mouse Monoclonal Antibody [Clone ID: S62-29]

CAT#: TA326438

Mouse monoclonal Copper Transporting ATPase2 Antibody

Specifications

Product Data

• Clone Name: S62-29
• Reactivities: Human, Mouse, Rat
• Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Synthetic peptide amino acids 3-21 (cytoplasmic N-terminus) of human Copper-transporting ATPase2
• Formulation: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: lot specific
• Purification: Protein G Purified
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: ATPase copper transporting beta
• Database Link:
  NP_000044
  Entrez Gene 11979 MouseEntrez Gene 24218 RatEntrez Gene 540 Human
  UniProt ID P35670
• Background: The copper efflux transporters ATP7A and ATP7B sequester intracellular copper into the vesicular secretory pathway for export from the cell. ATP7b is an important protein for copper transport and elimination of excess copper from the body. ATP7b transports metals in and out of cells using ATP. There are 3 known isoforms of the ATP7b gene; A is found in the liver, kidney, and brain, the shorter form B is found in brain tissue, and the third isoform, known as WND/140 KDA is found in mitochondria. Mutations in the ATP7b gene can cause Wilsons disease, an inherited disorder causing copper poisoning in the brain and liver, characterized by neurological symptoms and hepatic damage.
• Synonyms: PWD; WC1; WD; WND
• Note: Detects ~160kDa in rat brain membrane preparations

Reference Data

• Protein Families: Druggable Genome, Transmembrane