Superoxide Dismutase 1 (SOD1) Rabbit Polyclonal Antibody [Clone ID: N/A]

CAT#: TA326384

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Rabbit polyclonal SOD (Cu/Zn) Antibody



USD 430.00


Availability*
5 Days

Size
    • 100 ug


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Specifications

Product Data
Clone Name N/A
Applications IF, WB
Recommended Dilution 0.2ug/ml was sufficient for detection of Cu/Zn SOD in 20ug of HeLa cell lysate
Reactivity Bovine, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Sheep, Xenopus, Dog, Pig, Coral
Host Rabbit
Clonality Polyclonal
Immunogen Human Cu/Zn SOD
Formulation PBS pH7.0, 50% glycerol, 0.09% sodium azide
Concentration lot specific
Purification Affinity (antigen) Purified
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name superoxide dismutase 1, soluble
Background Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body . It works by catalyzing the dismutation of the superoxide radical O2¯to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase . In general, SODs play a major role in antioxidant defense mechanisms . There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge . The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extracellular space. SOD3 can also be distinguished by its heparin-binding capacity .
Synonyms ALS; ALS1; HEL-S-44; homodimer; hSod1; IPOA; SOD
Note Detects a ~23kDa (human) and 19kDa (other species) proteins corresponding to the molecular mass of Cu/Zn superoxide dismutase (SOD) on SDS PAGE immunoblots.
Reference Data
Protein Families Druggable Genome
Protein Pathways Amyotrophic lateral sclerosis (ALS), Huntington's disease, Prion diseases
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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