RRM1 Rabbit Polyclonal Antibody

CAT#: TA323395

Anti-RRM1 Rabbit Polyclonal Antibody

Product Images

Gel: 10%SDS-PAGE Lysate: 50 μg Lane 1-2: Hela cells 231 cells Primary antibody: TA323395 (RRM1 Antibody) at dilution 1/200 Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution Exposure time: 1 minute

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323395 (RRM1 Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human liver cancer tissue using TA323395 (RRM1 Antibody) at dilution 1/15, treated with fusion protein. (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA323395 (RRM1 Antibody) at dilution 1/15 (Original magnification: ×200)

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  Immunohistochemistry of paraffin-embedded Human tonsil tissue using TA323395 (RRM1 Antibody) at dilution 1/15, treated with fusion protein. (Original magnification: ×200)

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Specifications

Product Data

• Applications: IHC, WB
• Recommended Dilution: WB: 200-1000
  WB positive control: Hela and 231 cells
  IHC: 25-100
  Positive control: Human liver cancer
  Predicted cell location: Cytoplasm
• Reactivities: Human, Mouse
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Fusion protein corresponding to C terminal 226 amino acids of human ribonucleotide reductase M1
• Formulation: PBS pH7.3, 0.05% NaN3, 50% glycerol
• Concentration: lot specific
• Purification: Antigen affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 90 kDa
• Gene Name: ribonucleotide reductase catalytic subunit M1
• Database Link:
  NP_001024
  Entrez Gene 20133 MouseEntrez Gene 6240 Human
  UniProt ID P23921
• Background: This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase; an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5; an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome; Wilms tumor; rhabdomyosarcoma; adrenocrotical carcinoma; and lung; ovarian; and breast cancer. This gene may play a role in malignancies and disease that involve this region.
• Synonyms: R1; RIR1; RR1

Reference Data

• Protein Families: Druggable Genome
• Protein Pathways: Glutathione metabolism, Metabolic pathways, Purine metabolism, Pyrimidine metabolism