Amyloid Precursor Protein (APP) Rabbit Polyclonal Antibody

CAT#: TA308848

Rabbit Polyclonal antibody to beta Amyloid (amyloid beta (A4) precursor protein)

Product Images

Sample (30 ug of whole cell lysate). A:Hep G2. 7.5% SDS PAGE. TA308848 diluted at 1:1500

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  Sample (30 ug of whole cell lysate). A:NIH-3T3 7.5% SDS PAGE. TA308848 diluted at 1:1000.

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  Immunohistochemical analysis of paraffin-embedded Tonsil, plasma cells, using beta A4 Amyloid (TA308848) antibody (10 ug/ml).

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  beta Amyloid antibody [C2C3], C-term detects APP protein at cytoplasm by confocal immunofluorescent analysis. Sample: A431 cells were fixed in ice-cold MeOH for 5 min. Green: APP protein stained by beta Amyloid antibody [C2C3], C-term (TA308848) diluted a

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human, Mouse (Predicted: Dog, Pig, Chimpanzee, Bovine)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant fragment corresponding to a region within amino acids 602 and 770 of beta Amyloid (Uniprot ID#P05067)
• Formulation: 1XPBS, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 87 kDa
• Gene Name: amyloid beta precursor protein
• Database Link:
  NP_001129603
  Entrez Gene 11820 MouseEntrez Gene 403407 DogEntrez Gene 351 Human
  UniProt ID P05067
• Background: This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq]
• Synonyms: AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2
• Note: Seq homology of immunogen across species: Dog (100%), Pig (100%), Chimpanzee (100%), Bovine (100%)

Reference Data

• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Alzheimer's disease