Hsp22 (HSPB8) Rabbit Polyclonal Antibody

CAT#: TA308596

Rabbit Polyclonal antibody to HSP22 (heat shock 22kDa protein 8)

Product Images

Sample (30 ug whole cell lysate). A:293T whole cell lysate. B:A431. 12% SDS PAGE. TA308596 diluted at 1:1000

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  Immunohistochemical analysis of paraffin-embedded LUNG SCC, using HSP22 (TA308596) antibody at 1:500 dilution.

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  Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using HSPB8 (TA308596) antibody at 1:200 dilution.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: ICC/IF:1:100-1:1000; IHC:1:100-1:1000; WB:1:500-1:3000
• Reactivities: Human (Predicted: Rat, Dog, Bovine, Rhesus Monkey, Mouse)
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Synthetic peptide corresponding to a region within amino acids 134 and 196 of HSP22 (Uniprot ID#Q9UJY1)
• Formulation: 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
• Concentration: lot specific
• Purification: Purified by antigen-affinity chromatography.
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 22 kDa
• Gene Name: heat shock protein family B (small) member 8
• Database Link:
  NP_055180
  Entrez Gene 80888 MouseEntrez Gene 113906 RatEntrez Gene 403553 DogEntrez Gene 26353 Human
  UniProt ID Q9UJY1
• Background: The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq]
• Synonyms: CMT2L; DHMN2; E2IG1; H11; HMN2; HMN2A; HSP22
• Note: Seq homology of immunogen across species: Mouse (85%), Rat (85%), Dog (100%), Rhesus Monkey (100%), Bovine (92%)

Reference Data

• Protein Families: Druggable Genome, Protein Kinase