TCCR (IL27RA) Rabbit Polyclonal Antibody

CAT#: TA306081

Rabbit Polyclonal TCCR Antibody

Product Images

Western blot analysis of TCCR expression in human spleen tissue lysate with TCCR antibody at 1 ug /ml.

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  mmunohistochemistry of TCCR in human spleen tissue with TCCR antibody at 5 ug/ml.

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  Immunofluorescence of TCCR in Human Spleen cells with TCCR antibody at 20 ug/mL.

Specifications

Product Data

• Applications: IF, IHC, WB
• Recommended Dilution: WB: 1 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
• Reactivities: Human
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: TCCR antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of human TCCR precursor This sequence is identical to that of mouse TCCR.
• Formulation: PBS containing 0.02% sodium azide.
• Concentration: 1ug/ul
• Purification: Affinity chromatography purified via peptide column
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Gene Name: interleukin 27 receptor subunit alpha
• Database Link:
  NP_004834
  Entrez Gene 9466 Human
  UniProt ID Q6UWB1
• Background: Upon antigen challenge, T-helper cells differentiate into two functional distinct subsets, Th1 and Th2. Th1 cells produce IL-2, IFN-gamma and lymphotoxin-beta that augment cell mediated immune response while Th2 cells secrete IL-4, IL-5, and IL-10 that enhance humoral immunity. The function of T-helper cells is regulated by cytokines. A novel cytokine receptor was recently identified and cloned (1,2). It is a new member in the type I cytokine receptor family and designated TCCR for T-cell cytokine receptor and WSX-1 (1,2). TCCR deficient mice had impaired Th1 responses to protein antigen challenge, including decreased levels of IFN-gamma and Th1-dependent antibody IgG2a . TCCR is predominately expressed in thymus, spleen, lymph notes and peripheral blood leukocytes.
• Synonyms: CRL1; IL-27RA; IL27R; TCCR; WSX1; zcytor1

Reference Data

• Protein Families: Druggable Genome, Transmembrane