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LAYN, also known as layilin, is a type I transmembrane protein that can bind to actin cytoskeleton-associated protein talin and extracellular matrix component hyaluronan, supporting its role in cell-cell or cell-matrix interaction. In solid tumors, LAYN is enriched in tumor-infiltrating T cells, including immuno-suppressive regulatory T cells (Treg) and exhausted cytotoxic T cells (PD-1hiCTLA-4hi CD8+), and its presence in Treg is regarded as a poor prognosis in cancer patients

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