CD3E (NM_000733) Human Recombinant Protein

CAT#: TP762714

Purified recombinant protein of Human CD3e molecule, epsilon (CD3-TCR complex) (CD3E), 23Asp-126Asp, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Coomassie blue staining of purified CD3E protein (Cat #TP762714). The protein was produced from E.coli.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region (23Asp-126Asp) of CD3E
• Tag: N-His
• Predicted MW: 14.0 kDa
• Concentration: >0.05 ug/ul as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, 150mM NaCl, 10% glycerol, pH8.0, 1% SKL
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_000724
• Locus ID: 916
• UniProt ID: P07766
• Cytogenetics: 11q23.3
• Refseq Size: 1534
• Refseq ORF: 621
• Synonyms: IMD18; T3E; TCRE
• Summary: The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Hematopoietic cell lineage, Primary immunodeficiency, T cell receptor signaling pathway