ABCB4 (NM_018849) Human Recombinant Protein

CAT#: TP762713

Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 4 (ABCB4), transcript variant B, 1Met-60Gly GlyGlyGlyGlySer 600Ile-700Val, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Coomassie blue staining of purified ABCB4 protein (Cat #TP762713). The protein was produced from E.coli.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region (1Met-60Gly GlyGlyGlyGlySer 600Ile-700Val) of ABCB4
• Tag: N-His
• Predicted MW: 20.7 kDa
• Concentration: >0.05 ug/ul as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 25mM Tris, 150mM NaCl, 10% glycerol, pH8.0, 1% SKL
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for at least 1 year from receipt of products under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_061337
• Locus ID: 5244
• UniProt ID: P21439
• Cytogenetics: 7q21.12
• Refseq Size: 3988
• Refseq ORF: 3858
• Synonyms: ABC21; GBD1; ICP3; MDR2; MDR2/3; MDR3; PFIC-3; PGY3
• Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: ABC transporters