Nav1.5 (SCN5A) (NM_198056) Human Recombinant Protein

CAT#: TP762490

Purified recombinant protein of Human sodium channel, voltage-gated, type V, alpha subunit (SCN5A), transcript variant 1, 450Ile-650Val, with N-terminal His tag, expressed in E.coli, 50ug

Product Images

Purified recombinant protein SCN5A was analyzed by SDS-PAGE gel and Coomossie Blue Staining.

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A DNA sequence encoding the region (450Ile-650Val) of SCN5A
• Tag: N-His
• Predicted MW: 23.9kDa
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: 50 mM Tris-HCl, pH 8.0, 8 M urea
• Note: For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
• Storage: Store at -80°C after receiving vials.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.

Reference Data

• RefSeq: NP_932173
• Locus ID: 6331
• UniProt ID: Q14524
• Cytogenetics: 3p22.2
• Refseq Size: 8527
• Refseq ORF: 6048
• Synonyms: CDCD2; CMD1E; CMPD2; HB1; HB2; HBBD; HH1; ICCD; IVF; LQT3; Nav1.5; PFHB1; SSS1; VF1
• Summary: The protein encoded by this gene is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. This protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Defects in this gene are a cause of long QT syndrome type 3 (LQT3), an autosomal dominant cardiac disease. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome, Ion Channels: Sodium, Transmembrane