BMP2 (NM_001200) Human Recombinant Protein

CAT#: TP750012

Recombinant protein of human Bone Morphogenetic Protein-2 (BMP2) produced in E. coli.

 Product Datasheet for 'TP750012'

 Cited in 1 publication.

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USD 411.00

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    • 20 ug

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Product Data
Description Recombinant protein of human Bone Morphogenetic Protein-2 (BMP2) produced in E. coli.
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region (Gln283-Arg396) of human BMP2
Tag Tag Free
Predicted MW 13 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 10mM sodium citrate, pH 3.5. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Bioactivity Measured by its ability to induce alkaline phosphatase production in ATDC5 cells. ED50 for this effect is typically 36 - 55 ng/ml.
Endotoxin <0.1 EU per 1 µg of the protein by the LAL
Reference Data
RefSeq NP_001191
Locus ID 650
Refseq Size 1547
Cytogenetics 20p12.3
Refseq ORF 1188
Synonyms BDA2; BMP2A
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Stem cell relevant signaling - TGFb/BMP signaling pathway, Secreted Protein, ES Cell Differentiation/IPS, Transmembrane, Adult stem cells, Cancer stem cells, Embryonic stem cells, Induced pluripotent stem cells, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway, Pathways in cancer, Basal cell carcinoma

Citations (1)


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