BMP2 (NM_001200) Human Recombinant Protein

CAT#: TP750012

Recombinant protein of human Bone Morphogenetic Protein-2 (BMP2) produced in E. coli.


 Product Datasheet for 'TP750012'

 Cited in 1 publication.

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USD 411.00


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    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human Bone Morphogenetic Protein-2 (BMP2) produced in E. coli.
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence A DNA sequence encoding the region (Gln283-Arg396) of human BMP2
Tag Tag Free
Predicted MW 13 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 10mM sodium citrate, pH 3.5.
Bioactivity Measured?by?its?ability?to?induce?alkaline?phosphatase?production in?ATDC5?cells. ED50 for this effect is typically 36 - 55 ng/ml.
Co-immunoprecipitation (PMID: 28009989)
Endotoxin <0.1 EU per 1 µg of the protein by the LAL
Reference Data
RefSeq NP_001191
Locus ID 650
Refseq Size 1547
Cytogenetics 20p12.3
Refseq ORF 1188
Synonyms BDA2; BMP2A
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, Embryonic stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Secreted Protein, Stem cell relevant signaling - TGFb/BMP signaling pathway, Transmembrane
Protein Pathways Basal cell carcinoma, Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, Pathways in cancer, TGF-beta signaling pathway

Citations (1)

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