BMP2 (NM_001200) Human Recombinant Protein

CAT#: TP720011

Recombinant protein of human bone morphogenetic protein 2 (BMP2), the domain of Gln283-Arg396

 Product Datasheet for 'TP720011'

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USD 299.00

2 Weeks

    • 10 ug

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Product Data
Description Recombinant protein of human bone morphogenetic protein 2 (BMP2), the domain of Gln283-Arg396
Species Human
Expression Host E.Coli
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC214586, encoding the mature peptide (Gln283-Arg396) of human BMP2
Tag Tag Free
Predicted MW 13 kDa
Concentration Resuspend the protein to the desired concentration in proper buffer.
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 µM filtered solution of 50mM HAc. Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Bioactivity ED50 is less than 50 ng/ml as determined by the cytolysis of MC3T3-E1 cells. Specific Activity of 2.0 x 104 IU/mg
Endotoxin < 0.1 EU per µg protein as determined by LAL test
Reference Data
RefSeq NP_001191
Locus ID 650
Refseq Size 1547
Cytogenetics 20p12.3
Refseq ORF 1188
Synonyms BDA2; BMP2A
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone and cartilage development. Duplication of a regulatory region downstream of this gene causes a form of brachydactyly characterized by a malformed index finger and second toe in human patients. [provided by RefSeq, Jul 2016]
Protein Families Stem cell relevant signaling - TGFb/BMP signaling pathway, Secreted Protein, ES Cell Differentiation/IPS, Transmembrane, Adult stem cells, Cancer stem cells, Embryonic stem cells, Induced pluripotent stem cells, Druggable Genome
Protein Pathways Cytokine-cytokine receptor interaction, Hedgehog signaling pathway, TGF-beta signaling pathway, Pathways in cancer, Basal cell carcinoma


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