DKK1 Human Recombinant Protein

CAT#: TP728067

Biotinylated Human DKK-1 (C-Avi-6His)

Specifications

Product Data

• Species: Human
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Thr32-His266
• Tag: C-Avi-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS,pH7.4.
• Note: Biotinylated Recombinant Human Dickkopf-related protein 1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a AVI, 6His tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 22943
• UniProt ID: O94907
• Summary: Dickkopf-related protein 1(DKK-1), is a member of the dickkopf family. DKK1 secreted proteins with two cysteine-rich domains separated by a linker region. It antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.