Il2 Rat Recombinant Protein

CAT#: TP727730

Recombinant Rat Interleukin-2/IL-2 (C-6His)

Specifications

Product Data

• Species: Rat
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Ala21-Gln155
• Tag: C-His
• Buffer: Supplied as a 0.2 um filtered solution of 5mM NaH2PO4, 5mM Citric acid, 150mM NaCl, pH4.0.
• Note: Recombinant Rat Interleukin-2 is produced by our Mammalian expression system and the target gene encoding Ala21-Gln155 is expressed with a 6His tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 116562
• UniProt ID: P17108
• Summary: Interleukin-2(IL-2)is a O-glycosylated four α-helix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, γδ T cells, B cells, dendritic cells, and eosinophils. Mature rat IL-2 shares 66% and 73% amino acid sequence identity with human and mouse IL-2,respectively. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes.