Cx3cl1 Mouse Recombinant Protein

CAT#: TP727169

Recombinant Mouse C-X3-C Motif Chemokine 1/CX3CL1/Fractalkine (C-6His)

Specifications

Product Data

• Species: Mouse
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Gln25-Arg337
• Tag: C-His
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Note: Recombinant Mouse C-X3-C motif chemokine 1 is produced by our Mammalian expression system and the target gene encoding Gln25-Arg337 is expressed with a 6His tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 20312
• UniProt ID: O35188
• Summary: Fractalkine(CX3CL1) is a single-pass type I membrane protein and belongs to the intercrine delta family. It consists of an extracellular NH2-terminal domain, a mucin-like stalk, a transmembrane α helix, and a short cytoplasmic tail. CX3CL1 exists in two forms: as a membrane-anchored or as a shed 80-95K glycoprotein. Soluble CX3CL1 is generated by limited proteolysis on the cell surface, and a disintegrin and metallopeptidase 10 (ADAM10) and ADAM17/tumor necrosis factor-α-converting enzyme (ADAM17/TACE) participate in this shedding. It has been suggested that ADAM10 acts in the constitutive shedding, and ADAM17 acts in response to cell activation. The protein may play a role in regulating leukocyte adhesion and migration processes at the endothelium.