CD59 Human Recombinant Protein
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Specifications
Product Data | |
Species | Human |
Protein Source | Human |
Expression cDNA Clone or AA Sequence |
Leu26-Asn102
|
Tag | C-6His |
Buffer | Lyophilized from a 0.2 um filtered solution of PBS, pH7.4. |
Note | Recombinant Human CD59 Glycoprotein is produced by our Mammalian expression system and the target gene encoding Leu26-Asn102 is expressed with a 6His tag at the C-terminus. |
Stability | 12 months from date of despatch |
Reference Data | |
Locus ID | 966 |
UniProt ID | P13987 |
Summary | CD59, also known as membrane attack complex inhibition factor (MACIF), Protectin, 1F5 antigen, HRF-20 and MIRL, is an approximately 20 kDa GPI anchored glycoprotein that is an important regulator of the complement system in blood. CD59 is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 was first identified as a regulator of the terminal pathway of complement. It acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. CD59 is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. |
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