Ntrk3 Mouse Recombinant Protein

CAT#: TP726722

Recombinant Mouse TrkC (C-6His)

Specifications

Product Data

• Species: Mouse
• Protein Source: Human
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Cys32-Thr429
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.4.
• Note: Recombinant Mouse NT-3 Growth Factor Receptor is produced by our Mammalian expression system and the target gene encoding Cys32-Thr429 is expressed with a 6His tag at the C-terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 18213
• UniProt ID: Q6VNS1
• Summary: Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT-3, TrkB binds BDNF, NT-3 and NT-4/5, and TrkC only binds NT-3. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system. Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.