Calprotectin (S100A8) Human Recombinant Protein

CAT#: TP724696

Recombinant Human S100 Calcium Binding Protein S100A8/S100A9 Heterodimer (C-His)

Specifications

Product Data

• Species: Human
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  M1-E93 & M1-P114
• Tag: C-6His
• Buffer: Supplied as a 0.2 um filtered solution of 2umM HEPES, 15umM NaCl, 10% Glycerol, 2.umM EDTA, pH7.4.
• Note: Recombinant Human S100A8/S100A9 Heterodimer is produced by E.coli. The target gene encoding M1-E93 &; M1-P114 is expressed with a 6His tag at the C terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 6279
• UniProt ID: P05109
• Summary: S100A8 and S100A9 are pro-inflammatory members of the S100 family of secreted calcium binding proteins. They are produced by neutrophils and monocytes, and forms Ca2+-dependent heterodimer/heterotetramer complexes (known as calprotectin). Calprotectin (S100A8/A9) is upregulated at sites of inflammation (e.g. psoriasis, rheumatoid arthritis, cardiac ischemia). It is involved in facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase.