IL22 Human Recombinant Protein

CAT#: TP724655

Recombinant Human Interleukin-22/IL-22 (C-His)

Specifications

Product Data

• Species: Human
• Protein Source: Human 293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  A34-I179
• Tag: C-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of PBS, pH7.2
• Note: Recombinant Human Interleukin-22 is produced by Human 293 Cells. The target gene encoding A34-I179 is expressed with a 6His tag at the C terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 50616
• UniProt ID: Q9GZX6
• Summary: Interleukin-22 (IL22) is a cytokine that belongs to the IL-10 family or IL-10 superfamily, a class of potent mediators of cellular inflammatory responses. IL-22 is produced by activated DC and T cells and initiates innate immune responses against bacterial pathogens especially in epithelial cells such as respiratory and gut epithelial cells. IL-22 initiated its biological activity by binding to a cell-surface complex composed of IL-22R1 and IL-10R2 receptor chains and further regulated by interactions with a soluble binding protein IL-22BP. IL-22 can contribute to immune disease through the stimulation of inflammatory responses, S1s and defensins. IL-22 also promotes hepatocyte survival in the liver and epithelial cells in the lung and gut.