ALDH1A2 Human Recombinant Protein

CAT#: TP724620

Recombinant Human Aldehyde Dehydrogenase 1-A2/ALDH1A2 (N-His)

Specifications

Product Data

• Species: Human
• Protein Source: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Met1-Ser518
• Tag: N-6His
• Buffer: Lyophilized from a 0.2 um filtered solution of 20mM HEPES,150mM KCl,1mM β-ME ,0.5mM EDTA ,pH7.5.
• Note: Recombinant Human Aldehyde Dehydrogenase 1-A2 is produced by E.coli. The target gene encoding Met1-Ser518 is expressed with a 6His tag at the N terminus.
• Stability: 12 months from date of despatch

Reference Data

• Locus ID: 8854
• UniProt ID: O94788
• Summary: Aldehyde dehydrogenase 1 family member A2 (ALDH1A2), also known as retinaldehyde dehydrogenase 2 (RALDH2), belongs to the aldehyde dehydrogenase family which contains two members, the ALDH1 s (ALDH1A1, ALDH1A2 and ALDH1A3) and the 9-cis retinaldehyde dehydrogenase ALDH8 s. ALDH1A2 is a key enzyme that converts retinoic acid (RA) to retinaldehyde. RA is a paracrine hormone signaling molecule that functions in developing and adult tissues. ALDH1A2 was also found to regulate normal and tumor cell growth and differentiation in several cancers. Studies showed that ALDH1A2 expression is increased after the appearance of AraC resistance in clinical cases, which means this protein is effective in AraC resistance.