PPT1 (NM_000310) Human Recombinant Protein

CAT#: TP721098XL

Purified recombinant protein of Human palmitoyl-protein thioesterase 1 (PPT1), transcript variant 1

Specifications

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Asp28-Gly306
• Tag: C-His
• Predicted MW: 32.3 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Provided lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Storage: Store at -80°C.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_000301
• Locus ID: 5538
• UniProt ID: P50897
• Cytogenetics: 1p34.2
• Refseq Size: 2504
• Refseq ORF: 918
• Synonyms: CLN1; INCL; PPT
• Summary: The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]
• Protein Families: Druggable Genome
• Protein Pathways: Fatty acid elongation in mitochondria, Lysosome, Metabolic pathways