DCK (NM_000788) Human Recombinant Protein

CAT#: TP720869L

Purified recombinant protein of Human deoxycytidine kinase (DCK)

Specifications

Product Data

• Species: Human
• Expression Host: E. coli
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  Met1-Leu260
• Tag: N-His&T7
• Predicted MW: 34 kDa
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Buffer: Provided lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl
• Endotoxin: Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
• Storage: Store at -80°C.
• Stability: Stable for at least 3 months from date of receipt under proper storage and handling conditions.

Reference Data

• RefSeq: NP_000779
• Locus ID: 1633
• UniProt ID: P27707, F5CTF3
• Cytogenetics: 4q13.3
• Refseq Size: 2618
• Refseq ORF: 780
• Summary: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. [provided by RefSeq, Jul 2008]
• Protein Families: Druggable Genome
• Protein Pathways: Purine metabolism, Pyrimidine metabolism