DNA Ligase I (LIG1) (NM_000234) Human Recombinant Protein

CAT#: TP310760

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Recombinant protein of human ligase I, DNA, ATP-dependent (LIG1)


 Product Datasheet for 'TP310760'

 Cited in 1 publication.

  View other "LIG1" proteins (3)

USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human ligase I, DNA, ATP-dependent (LIG1)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 101.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Bioactivity Enzyme activity (PMID: 25921062)
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_000225
Locus ID 3978
Refseq Size 3083
Cytogenetics 19q13.33
Refseq ORF 2757
Synonyms MGC117397; MGC130025
Summary This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Protein Families Druggable Genome
Protein Pathways Base excision repair, DNA replication, Mismatch repair, Nucleotide excision repair

Citations (1)

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HUMAN PROREINS 101