MDC (CCL22) (NM_002990) Human Mass Spec Standard

CAT#: PH306578

CCL22 MS Standard C13 and N15-labeled recombinant protein (NP_002981)

Product Images

Coomassie blue staining of purified CCL22 protein (Cat# TP306578). The protein was produced from HEK293T cells transfected with CCL22 cDNA clone (Cat# RC206578) using MegaTran 2.0 (Cat# TT210002).

Specifications

Product Data

• Tag: C-Myc/DDK
• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence: RC206578
• Predicted MW: 10.6 kDa
• Protein Sequence:
  Sequence Link

  >RC206578 protein sequence
  Red=Cloning site Green=Tags(s)
  
  MARLQTALLVVLVLLAVALQATEAGPYGANMEDSVCCRDYVRYRLPLRVVKHFYWTSDSCPRPGVVLLTF
  RDKEICADPRVPWVKMILNKLSQ
  
  TRTRPLEQKLISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >0.05 µg/µL as determined by microplate BCA method
• Labeling Method: Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
• Buffer: 25 mM Tris-HCl, 100 mM glycine, pH 7.3
• Storage: Store at -80°C. Avoid repeated freeze-thaw cycles.
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.

Reference Data

• RefSeq: NP_002981
• RefSeq Size: 2933
• RefSeq ORF: 279
• Synonyms: A-152E5.1; ABCD-1; DC/B-CK; MDC; SCYA22; STCP-1
• Locus ID: 6367
• UniProt ID: O00626
• Cytogenetics: 16q21
• Summary: This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: Chemokine signaling pathway, Cytokine-cytokine receptor interaction