Cytochrome P450 Reductase (POR) (NM_000941) Human Mass Spec Standard

CAT#: PH302172

POR MS Standard C13 and N15-labeled recombinant protein (NP_000932)

  View other "Cytochrome P450 Reductase" proteins (3)

USD 3,255.00

3 Weeks*

    • 10 ug

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Frequently bought together (2)
Transient overexpression lysate of P450 (cytochrome) oxidoreductase (POR)
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POR (Cytochrome P450 Reductase) mouse monoclonal antibody, clone OTI5B3 (formerly 5B3)
    • 100 ul

USD 447.00

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Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC202172
Predicted MW 77.1 kDa
Protein Sequence
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_000932
RefSeq Size 2509
RefSeq ORF 2040
Synonyms CPR; CYPOR; P450R
Locus ID 5447
UniProt ID P16435
Cytogenetics 7q11.23
Summary This gene encodes an endoplasmic reticulum membrane oxidoreductase that is essential for multiple metabolic processes, including reactions catalyzed by cytochrome P450 proteins for metabolism of steroid hormones, drugs and xenobiotics. The encoded protein has a flavin adenine dinucleotide (FAD)-binding domain and a flavodoxin-like domain which bind two cofactors, FAD and FMN, that allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene cause a complex set of disorders, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome, that resemble those caused by defects in steroid metabolizing enzymes such as aromatase, 21-hydroxylase, and 17 alpha-hydroxylase. [provided by RefSeq, Aug 2020]
Protein Families Druggable Genome, P450, Transmembrane


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