Mouse Apobec3 activation kit by CRISPRa

CAT#: GA211109

Apobec3 CRISPRa kit - CRISPR gene activation of mouse apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Apobec3
• Locus ID: 80287
• Kit Components:

  GA211109G1, Apobec3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211109G2, Apobec3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211109G3, Apobec3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001160415, NM_001347041, NM_030255
• UniProt ID: Q99J72
• Synonyms: Apobec; Arp3; BC003314; Cem15; Rfv3
• Summary: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons.[UniProtKB/Swiss-Prot Function]