Mouse Chst15 activation kit by CRISPRa

CAT#: GA210776

Chst15 CRISPRa kit - CRISPR gene activation of mouse carbohydrate sulfotransferase 15

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Chst15
• Locus ID: 77590
• Kit Components:

  GA210776G1, Chst15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA210776G2, Chst15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA210776G3, Chst15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_029935, NM_001360768
• UniProt ID: Q91XQ5
• Synonyms: 4631426J05Rik; BRAG; GalNAcS-6ST; MAd5; mKIAA0598
• Summary: Sulfotransferase that transfers sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the C-6 hydroxyl group of the GalNAc 4-sulfate residue of chondroitin sulfate A and forms chondroitin sulfate E containing GlcA-GalNAc(4,6-SO(4)) repeating units. It also transfers sulfate to a unique non-reducing terminal sequence, GalNAc(4SO4)-GlcA(2SO4)-GalNAc(6SO4), to yield a highly sulfated structure similar to the structure found in thrombomodulin chondroitin sulfate. May also act as a B-cell receptor involved in BCR ligation-mediated early activation that mediate regulatory signals key to B-cell development and/or regulation of B-cell-specific RAG expression; however such results are unclear in vivo (By similarity).[UniProtKB/Swiss-Prot Function]