Mouse Frmd8 activation kit by CRISPRa

CAT#: GA207341

Frmd8 CRISPRa kit - CRISPR gene activation of mouse FERM domain containing 8

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Frmd8
• Locus ID: 67457
• Kit Components:

  GA207341G1, Frmd8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA207341G2, Frmd8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA207341G3, Frmd8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_026169
• UniProt ID: Q3UFK8
• Synonyms: 1200004M23Rik; 2310035N23Rik; 4931429L16Rik; AU018809
• Summary: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway (PubMed:29897333). By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (By similarity). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (By similarity).[UniProtKB/Swiss-Prot Function]