Mouse Yap1 activation kit by CRISPRa

CAT#: GA204664

Yap1 CRISPRa kit - CRISPR gene activation of mouse yes-associated protein 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Yap1
• Locus ID: 22601
• Kit Components:

  GA204664G1, Yap1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204664G2, Yap1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204664G3, Yap1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001171147, NM_009534
• UniProt ID: P46938
• Synonyms: AI325207; Yap; Yap65; Yki; Yorkie
• Summary: This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]