Mouse Cnot7 activation kit by CRISPRa

CAT#: GA203323

Cnot7 CRISPRa kit - CRISPR gene activation of mouse CCR4-NOT transcription complex, subunit 7

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Cnot7
• Locus ID: 18983
• Kit Components:

  GA203323G1, Cnot7 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203323G2, Cnot7 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203323G3, Cnot7 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001271542, NM_001271543, NM_011135, NM_001361938, NM_001361939
• UniProt ID: Q60809
• Synonyms: AU022737; CAF-1; Caf1; Pop2
• Summary: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.[UniProtKB/Swiss-Prot Function]