Mouse Nr1i2 activation kit by CRISPRa

CAT#: GA202960

Nr1i2 CRISPRa kit - CRISPR gene activation of mouse nuclear receptor subfamily 1, group I, member 2

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Nr1i2
• Locus ID: 18171
• Kit Components:

  GA202960G1, Nr1i2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202960G2, Nr1i2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202960G3, Nr1i2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001098404, NM_010936
• UniProt ID: O54915
• Synonyms: mPXR; PXR; PXR.1; PXR.2; PXR1; SXR
• Summary: Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand-binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN).[UniProtKB/Swiss-Prot Function]