Mouse Cd44 activation kit by CRISPRa

CAT#: GA200626

Cd44 CRISPRa kit - CRISPR gene activation of mouse CD44 antigen

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: Cd44
• Locus ID: 12505
• Kit Components:

  GA200626G1, Cd44 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200626G2, Cd44 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200626G3, Cd44 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001039150, NM_001039151, NM_001177785, NM_001177786, NM_001177787, NM_009851
• UniProt ID: P15379
• Synonyms: AU023126; AW121933; AW146109; HERMES; Ly-24; Pgp-1
• Summary: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:8343954, PubMed:25065622). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (By similarity).[UniProtKB/Swiss-Prot Function]