Mouse C1qa activation kit by CRISPRa

CAT#: GA200459

C1qa CRISPRa kit - CRISPR gene activation of mouse complement component 1, q subcomponent, alpha polypeptide

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: C1qa
• Locus ID: 12259
• Kit Components:

  GA200459G1, C1qa gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA200459G2, C1qa gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA200459G3, C1qa gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_007572
• UniProt ID: P98086
• Synonyms: AI255395; C1q
• Summary: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes.[UniProtKB/Swiss-Prot Function]