Human CCL3L3 activation kit by CRISPRa

CAT#: GA118404

CCL3L3 CRISPRa kit - CRISPR gene activation of human C-C motif chemokine ligand 3 like 3

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: CCL3L3
• Locus ID: 414062
• Kit Components:

  GA118404G1, CCL3L3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA118404G2, CCL3L3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA118404G3, CCL3L3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001001437
• UniProt ID: P16619
• Synonyms: 464.2; D17S1718; G0S19-2; LD78; LD78BETA; SCYA3L; SCYA3L1
• Summary: This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility.[provided by RefSeq, Apr 2014]