Human ASPM activation kit by CRISPRa

CAT#: GA116913

ASPM CRISPRa kit - CRISPR gene activation of human abnormal spindle microtubule assembly

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: ASPM
• Locus ID: 259266
• Kit Components:

  GA116913G1, ASPM gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA116913G2, ASPM gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA116913G3, ASPM gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001206846, NM_018136
• UniProt ID: Q8IZT6
• Synonyms: ASP; Calmbp1; MCPH5
• Summary: This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]