Human NOL6 activation kit by CRISPRa

CAT#: GA112233

NOL6 CRISPRa kit - CRISPR gene activation of human nucleolar protein 6

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: NOL6
• Locus ID: 65083
• Kit Components:

  GA112233G1, NOL6 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA112233G2, NOL6 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA112233G3, NOL6 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_022917, NM_130793, NM_139235
• UniProt ID: Q9H6R4
• Synonyms: bA311H10.1; NRAP; UTP22
• Summary: The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]