Human TBX21 activation kit by CRISPRa

CAT#: GA109374

TBX21 CRISPRa kit - CRISPR gene activation of human T-box transcription factor 21

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: TBX21
• Locus ID: 30009
• Kit Components:

  GA109374G1, TBX21 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA109374G2, TBX21 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA109374G3, TBX21 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_013351
• UniProt ID: Q9UL17
• Synonyms: T-bet; T-PET; TBET; TBLYM
• Summary: This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]