Human Periostin (POSTN) activation kit by CRISPRa

CAT#: GA107282

POSTN CRISPRa kit - CRISPR gene activation of human periostin

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: POSTN
• Locus ID: 10631
• Kit Components:

  GA107282G1, Periostin gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA107282G2, Periostin gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA107282G3, Periostin gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001135934, NM_001135935, NM_001135936, NM_001286665, NM_001286666, NM_001286667, NM_001330517, NM_006475
• UniProt ID: Q15063
• Synonyms: OSF-2; OSF2; PDLPOSTN; PN
• Summary: This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing, and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]