Human Von Willebrand Factor (VWF) activation kit by CRISPRa

CAT#: GA105134

VWF CRISPRa kit - CRISPR gene activation of human von Willebrand factor

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: VWF
• Locus ID: 7450
• Kit Components:

  GA105134G1, Von Willebrand Factor gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105134G2, Von Willebrand Factor gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105134G3, Von Willebrand Factor gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000552
• UniProt ID: P04275
• Synonyms: F8VWF; VWD
• Summary: This gene encodes a glycoprotein involved in hemostasis. The encoded preproprotein is proteolytically processed following assembly into large multimeric complexes. These complexes function in the adhesion of platelets to sites of vascular injury and the transport of various proteins in the blood. Mutations in this gene result in von Willebrand disease, an inherited bleeding disorder. An unprocessed pseudogene has been found on chromosome 22. [provided by RefSeq, Oct 2015]