Human UFD1 activation kit by CRISPRa

CAT#: GA105065

UFD1 CRISPRa kit - CRISPR gene activation of human ubiquitin recognition factor in ER associated degradation 1

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: UFD1
• Locus ID: 7353
• Kit Components:

  GA105065G1, UFD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA105065G2, UFD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA105065G3, UFD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_001035247, NM_005659, NM_001362910
• UniProt ID: Q92890
• Synonyms: UFD1
• Summary: The protein encoded by this gene forms a complex with two other proteins, nuclear protein localization-4 and valosin-containing protein, and this complex is necessary for the degradation of ubiquitinated proteins. In addition, this complex controls the disassembly of the mitotic spindle and the formation of a closed nuclear envelope after mitosis. Mutations in this gene have been associated with Catch 22 syndrome as well as cardiac and craniofacial defects. Alternative splicing results in multiple transcript variants encoding different isoforms. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Jun 2009]