Human MAT1A activation kit by CRISPRa

CAT#: GA102821

MAT1A CRISPRa kit - CRISPR gene activation of human methionine adenosyltransferase 1A

Product Images

Specifications

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Symbol: MAT1A
• Locus ID: 4143
• Kit Components:

  GA102821G1, MAT1A gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA102821G2, MAT1A gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA102821G3, MAT1A gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.

Reference Data

• RefSeq: NM_000429
• UniProt ID: Q00266
• Synonyms: MAT; MATA1; SAMS; SAMS1
• Summary: This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency. [provided by RefSeq, Jul 2008]